Hutchinson M, Blandford S, Glynn D, Martin E A
Acta Neurol Scand. 1984 Aug;70(2):90-5. doi: 10.1111/j.1600-0404.1984.tb00808.x.
Brain-stem auditory evoked responses (BAERs) were examined in 178 patients with multiple sclerosis (MS) and compared to the frequency of abnormalities in visually evoked responses (VERs) and in CSF electrophoresis. In clinically definite MS, BAERs were abnormal in 61% and a significant relationship was noted between disability due to MS and the frequency and severity of BAER abnormalities. In suspected MS, BAERs showed evidence of a second lesion in 14% whereas VERs indicated a second lesion in 24%. Abnormal BAERs in patients with suspected MS with brain-stem signs were significantly associated with the presence of truncal and limb ataxia. In progressive possible MS, abnormal BAERs were found in 49% but indicated a second lesion in 35% of patients and were significantly related to the duration of illness. In progressive possible MS, abnormal VERs but not abnormal BAERs, were significantly associated with the presence of CSF oligoclonal IgG banding. Normal BAERs in association with clinical brain-stem abnormalities were found in 24% of patients with clinically definite MS, 50% with suspected MS and 33% with progressive possible MS.
对178例多发性硬化症（MS）患者进行了脑干听觉诱发电位（BAERs）检查，并与视觉诱发电位（VERs）和脑脊液电泳异常频率进行了比较。在临床确诊的MS中，BAERs异常率为61%，且MS所致残疾与BAER异常的频率和严重程度之间存在显著相关性。在疑似MS中，BAERs显示14%的患者有第二个病灶，而VERs显示24%的患者有第二个病灶。有脑干体征的疑似MS患者中，BAERs异常与躯干和肢体共济失调的存在显著相关。在进展性可能MS中，49%的患者BAERs异常，但35%的患者提示有第二个病灶，且与病程显著相关。在进展性可能MS中，VERs异常而非BAERs异常与脑脊液寡克隆IgG带的存在显著相关。在临床确诊的MS患者中，24%的患者BAERs正常但伴有临床脑干异常；疑似MS患者中，这一比例为50%；进展性可能MS患者中，这一比例为33%。
