多发性硬化症中的脑干听觉和视觉诱发电位

Brain stem auditory and visual evoked potentials in multiple sclerosis.

作者信息

Kjaer M

出版信息

Acta Neurol Scand. 1980 Jul;62(1):14-9. doi: 10.1111/j.1600-0404.1980.tb02999.x.

DOI:10.1111/j.1600-0404.1980.tb02999.x

Abstract

The diagnostic value of the checkerboard pattern-reversal visual evoked potential (VEP) and the random, low rate stimulated brain stem auditory evoked potential (BAEP) was compared in 99 patients with established or suspected multiple sclerosis (MS). In normal subjects examined by both techniques no abnormal recordings were found. In 49 patients with definite MS an incidence of abnormality was found in 100% of VEP and in 84% of BAEP recordings. In 50 patients with probable or possible MS an abnormal VEP was found in 70% and an abnormal BAEP in 50%. When the two examinations were combined, the diagnostic yield increased to 100 and 80%, respectively. 22 patients had only spinal symptoms; in these the VEP gave 73%, the BAEP 55% and the combination 82% abnormalities. The combination of the two techniques was found useful for demonstrating demyelinating lesions in the central nervous system, the diagnostic value being greatest when these lesions were clinically silent.

摘要

对99例确诊或疑似多发性硬化症（MS）患者的棋盘格模式翻转视觉诱发电位（VEP）和随机、低频率刺激脑干听觉诱发电位（BAEP）的诊断价值进行了比较。在接受这两种技术检查的正常受试者中，未发现异常记录。在49例确诊MS患者中，VEP记录的异常发生率为100%，BAEP记录的异常发生率为84%。在50例可能或疑似MS患者中，异常VEP的发生率为70%，异常BAEP的发生率为50%。当两种检查结合使用时，诊断阳性率分别提高到100%和80%。22例患者仅有脊髓症状；在这些患者中，VEP的异常率为73%，BAEP为55%，两者结合为82%。发现这两种技术结合使用有助于显示中枢神经系统的脱髓鞘病变，当这些病变在临床上无症状时，诊断价值最大。