Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, Jiangsu, PR China.
Medical School of Nantong University, Nantong University, Nantong 226001, Jiangsu, PR China.
ACS Biomater Sci Eng. 2023 Aug 14;9(8):4761-4769. doi: 10.1021/acsbiomaterials.3c00579. Epub 2023 Jul 9.
Since the physical properties are similar to native extracellular matrices, double network (DN) hydrogels have been studied extensively in the tissue engineering. However, the double chemical crosslinked DN hydrogel is limited by poor fatigue resistance. π-π stacking is a non-covalent bonding interaction, which is essential to maintain and self-assemble the three-dimensional structure of biological proteins and nucleic acids. In this study, a robust polyethylene glycol diacrylate (PEGDA)/FFK hybrid DN hydrogel was prepared by Michael addition and π-π stacking. The hybrid DN hydrogels with π-π stacking interactions have excellent mechanical strength and fatigue resistance. The DN FFK/PEGDA hydrogels reveal great biocompatibility and hemocompatibility. The DN hydrogels containing π-π stacking have the potential to fabricate robust hybrid DN hydrogels in drug release and tissue engineering.
由于其物理性质类似于天然细胞外基质，双网络（DN）水凝胶在组织工程中得到了广泛的研究。然而，双化学交联的 DN 水凝胶受到疲劳阻力差的限制。π-π 堆积是一种非共价键相互作用，对于维持和自组装生物蛋白质和核酸的三维结构至关重要。在这项研究中，通过迈克尔加成和 π-π 堆积制备了一种坚固的聚乙二醇二丙烯酸酯（PEGDA）/FFK 杂化双网络水凝胶。具有 π-π 堆积相互作用的杂化双网络水凝胶具有优异的机械强度和抗疲劳性。DN FFK/PEGDA 水凝胶表现出良好的生物相容性和血液相容性。含有 π-π 堆积的双网络水凝胶具有在药物释放和组织工程中制备坚固的杂化双网络水凝胶的潜力。
