Department of Anesthesiology & Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Osteoporosis, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pain Manag. 2023 Jun;13(6):363-372. doi: 10.2217/pmt-2023-0053. Epub 2023 Jul 9.
Cryoneurolysis is a potential therapy for peripheral mononeuropathies, but randomized studies of its effects on the duration of pain reduction are lacking. This retrospective cohort study evaluated the analgesic effects of cryoneurolysis on patients with refractory peripheral mononeuropathy. We included 24 patients who underwent ultrasound-guided cryoneurolysis between June 2018 and July 2022. The daily maximum pain level was recorded using a numerical rating scale before and 1, 3 and 6 months after the procedure. At 1 month, 54.2% of patients reported pain reduction of at least 30%. This percentage was significantly lower at 3 and 6 months (13.8 and 9.1%, respectively). Our results suggest that repeated cryoneurolysis may be a viable treatment for refractory mononeuropathy. Further investigations are needed.
冷冻神经松解术是治疗周围单神经病的一种潜在疗法，但缺乏关于其对疼痛缓解持续时间影响的随机研究。本回顾性队列研究评估了冷冻神经松解术对难治性周围单神经病患者的镇痛效果。我们纳入了 2018 年 6 月至 2022 年 7 月间接受超声引导下冷冻神经松解术的 24 名患者。在治疗前和治疗后 1、3 和 6 个月，使用数字评分量表记录每日最大疼痛水平。在 1 个月时，54.2%的患者报告疼痛缓解至少 30%。这一比例在 3 个月和 6 个月时显著降低（分别为 13.8%和 9.1%）。我们的结果表明，重复冷冻神经松解术可能是治疗难治性单神经病的一种可行治疗方法。需要进一步研究。
