DesRochers John, Fry Samantha, Khadr Arwa, Rana Neel, Siu Gilbert
Department of Medicine, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.
Department of Biomedical Research, Futures Forward Research Institute, Toms River, NJ, USA.
Pain Manag. 2024 Dec;14(12):665-671. doi: 10.1080/17581869.2024.2443380. Epub 2024 Dec 23.
Post-mastectomy pain syndrome is a common postoperative complication that can impact patient quality of life and function. The aim of this systematic review is to evaluate the effectiveness of cryoneurolysis as an intervention for the management of post-mastectomy pain.
A prospero-registered systematic review was performed following PRISMA 2020 guidelines. An initial screening consisted of 53 articles imported from the following databases: PubMed, Embase, Web of Science, Cochrane, and Scopus. Google Scholar and WorldCat were also searched to pull any further articles.
Three clinical trials, one case series, and one case report were included. Primary outcome measure of patient reported pain score (VAS or NRS) showed clinically significant reduction in pain in all five studies. Three of the studies also reported reduction in opioid use with cryoneurolysis intervention. A pooled effect size of Hedges g = -0.963, (95% CI [-1.55, -0.373]), with heterogeneity (I = 0.70).
Cryoneurolysis intervention shows promising and clinically significant relief in post-mastectomy pain in patients and further studies are encouraged.
乳房切除术后疼痛综合征是一种常见的术后并发症，会影响患者的生活质量和功能。本系统评价的目的是评估冷冻神经溶解术作为一种干预措施治疗乳房切除术后疼痛的有效性。
按照PRISMA 2020指南进行了一项在Prospero注册的系统评价。初步筛选包括从以下数据库导入的53篇文章：PubMed、Embase、科学网、Cochrane和Scopus。还检索了谷歌学术和WorldCat以获取更多文章。
纳入了三项临床试验、一项病例系列和一项病例报告。患者报告的疼痛评分（视觉模拟评分法或数字评定量表）的主要结局指标显示，在所有五项研究中疼痛均有临床显著减轻。其中三项研究还报告了冷冻神经溶解术干预使阿片类药物使用减少。合并效应量Hedges g = -0.963，（95%置信区间[-1.55，-0.373]）,异质性（I = 0.70）。
冷冻神经溶解术干预在减轻乳房切除术后患者疼痛方面显示出有前景且具有临床意义的效果，鼓励开展进一步研究。
