Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, United States.
Front Endocrinol (Lausanne). 2023 Jun 22;14:1187289. doi: 10.3389/fendo.2023.1187289. eCollection 2023.
Immunotherapies are a promising therapeutic option, yet for a variety of reasons, these treatments have achieved limited success against sarcomas. The immunosuppressive tumor microenvironment (TME) of sarcomas as well as lack of predictive biomarkers, decreased T-cell clonal frequency, and high expression of immunosuppressive infiltrating cells has thus far prevented major success using immunotherapies. By breaking down the TME into its individual components and understanding how the various cell types interact with each other as well as in the context of the complex immune microenvironment, can lead to effective therapeutic immunotherapy treatments, potentially improving outcomes for those with metastatic disease.
免疫疗法是一种很有前途的治疗选择，但由于种种原因，这些治疗方法在肉瘤治疗方面的效果有限。肉瘤的免疫抑制肿瘤微环境（TME）以及缺乏预测性生物标志物、T 细胞克隆频率降低、高表达免疫抑制浸润细胞，迄今为止，这些因素都阻止了免疫疗法的重大成功。通过将 TME 分解为其各个组成部分，并了解各种细胞类型如何相互作用以及在复杂的免疫微环境中的相互作用，可以为有效的治疗性免疫治疗提供依据，有可能改善转移性疾病患者的预后。
