Maalouly Michele, Saade Serena, Kurban Mazen
Department of Internal Medicine.
Department of Dermatology.
Dermatol Reports. 2022 Dec 29;15(2):9625. doi: 10.4081/dr.2023.9625. eCollection 2023 Jun 7.
Autoinflammatory diseases are characterized by bouts of systemic or localized inflammation in the absence of an infection. While some autoinflammatory diseases are caused by a single gene mutation, others have been shown to be multifactorial, involving a large array of genes coupled with environmental factors. Previous studies briefly elucidated the molecular mechanisms behind the many autoinflammatory diseases, focusing on the dysregulation of interleukin (IL)-1β or IL-18, nuclear factor- κB activation, and Interferons secretion. In this review, we precisely highlight the autoinflammatory disease-specific signalosomes, and we aim to provide a scaffold of the link between the various affected pathways.
自身炎症性疾病的特征是在没有感染的情况下出现全身性或局部性炎症发作。虽然一些自身炎症性疾病是由单个基因突变引起的，但其他疾病已被证明是多因素的，涉及大量基因以及环境因素。先前的研究简要阐明了许多自身炎症性疾病背后的分子机制，重点关注白细胞介素（IL）-1β或IL-18的失调、核因子-κB激活和干扰素分泌。在本综述中，我们精确地突出了自身炎症性疾病特异性信号小体，旨在提供各种受影响途径之间联系的框架。
