Enichen Elizabeth, Adams Robert B, Demmig-Adams Barbara
Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA, (EE, BDA); Physical Therapy of Boulder, Boulder, CO, USA, (RBA).
Am J Lifestyle Med. 2022 Mar 2;17(4):502-517. doi: 10.1177/15598276221078222. eCollection 2023 Jul-Aug.
This review evaluates physical activity as a candidate for an adjunct treatment, in conjunction with antiretroviral therapy (ART), for people living with HIV (PLWH). Evidence is summarized that chronic, non-resolving inflammation (a principal feature of immune system dysfunction) and a dysfunctional state of the gut environment are key factors in HIV infection that persist despite treatment with ART. In addition, evidence is summarized that regular physical activity may restore normal function of both the immune system and the gut environment and may thereby ameliorate symptoms and non-resolving inflammation-associated comorbidities that burden PLWH. Physicians who care for PLWH could thus consider incorporating physical activity into treatment plans to complement ART. It is also discussed that different types of physical activity can have different effects on the gut environment and immune function, and that future research should establish more specific criteria for the design of exercise regimens tailored to PLWH.
本综述评估了体育活动作为抗逆转录病毒疗法（ART）辅助治疗手段，用于人类免疫缺陷病毒感染者（PLWH）的可能性。综述总结了相关证据，即慢性、无法消退的炎症（免疫系统功能障碍的主要特征）和肠道环境功能失调是HIV感染的关键因素，尽管接受了ART治疗，但这些因素依然存在。此外，综述还总结了相关证据，即规律的体育活动可能恢复免疫系统和肠道环境的正常功能，从而改善困扰PLWH的症状以及与无法消退的炎症相关的合并症。因此，照顾PLWH的医生可考虑将体育活动纳入治疗方案，以补充ART治疗。文中还讨论了不同类型的体育活动对肠道环境和免疫功能可能产生不同影响，未来的研究应建立更具体的标准，以设计适合PLWH的运动方案。
