Rezaei Homa, Rahimpour Elaheh, Martinez Fleming, Jouyban Abolghasem
Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Heliyon. 2023 Jun 19;9(6):e17402. doi: 10.1016/j.heliyon.2023.e17402. eCollection 2023 Jun.
This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van't Hoff and Gibbs equation.
本研究通过实验测量和数学关联，探讨了去铁酮作为口服铁螯合剂在丙二醇和异丙醇非水混合物中的热力学性质、饱和溶解度值及溶剂化行为。去铁酮的溶解度与温度和丙二醇质量分数均呈正相关。采用四个数学模型对固液平衡数据进行关联，小于3.6%的低平均相对偏差值表明计算数据与实验数据吻合良好。还根据范特霍夫方程和吉布斯方程研究了去铁酮溶解的表观热力学行为。
