Dabagh Fatemeh, Khalili Fatemeh, Zarghampour Aynaz, Hemmati Salar, Hanaee Jalal, Rahimpour Elaheh, Jouyban Abolghasem
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Chem. 2024 May 9;18(1):84. doi: 10.1186/s13065-024-01188-1.
This study aimed to measure both the solubility and thermodynamics of salicylic acid in binary solvent mixtures of (2-propanol + ethylene glycol) and (2-propanol + propylene glycol) at different temperatures in the range of 293.2-313.2 K. The experimental solubility data were analyzed using various linear and nonlinear cosolvency models, such as the van'tt Hoff, Jouyban-Acree, Jouyban-Acree-van'tt Hoff, mixture response surface and modified Wilson models and to evaluate the models, the mean relative deviations of the back-calculated solubility data were compared with experimental values. Through this analysis, the apparent thermodynamic parameters, including Gibbs energy, enthalpy, and entropy were calculated using the van'tt Hoff and Gibbs equations for this system. Additionally, the density values for salicylic acid saturated mixtures were also measured and represent mathematically using the Jouyban-Acree model.
本研究旨在测定水杨酸在（2-丙醇+乙二醇）和（2-丙醇+丙二醇）二元混合溶剂中，于293.2 - 313.2 K不同温度下的溶解度和热力学性质。利用各种线性和非线性共溶剂模型，如范特霍夫、朱伊班-阿克里、朱伊班-阿克里-范特霍夫、混合响应面和修正威尔逊模型，对实验溶解度数据进行分析。为评估这些模型，将反算溶解度数据的平均相对偏差与实验值进行比较。通过该分析，使用该系统的范特霍夫方程和吉布斯方程计算了包括吉布斯自由能、焓和熵在内的表观热力学参数。此外，还测量了水杨酸饱和混合物的密度值，并使用朱伊班-阿克里模型进行数学表示。
