Faggian Guido, Cesaro Antonio, Faggian Roberto, Vitagliano Arcangelo, Del Piano Carlo, Del Piano Domenico, Salzano Michela, Diglio Andrea, Faggian Angela
Sezione Diagnostica per Immagini e Radioterapia Univ. Federico II Napoli.
UOSD Nefrologia ed Emodialisi, P.O. Moscati, Aversa (CE), Italia.
G Ital Nefrol. 2023 Jun 29;40(3):2023-vol3.
Lactic acidosis is a potential adverse event related to metformin therapy. Although metformin-associated lactic acidosis (MALA) is a rare condition (about 10 cases / 100,000 patients / year), new cases continue to be reported, with a mortality of 40-50%. We describe two clinical cases characterized by severe metabolic acidosis, hyperlactacidemia, and acute renal injury. The first also with NSTEMI, successfully treated.
乳酸性酸中毒是与二甲双胍治疗相关的一种潜在不良事件。尽管二甲双胍相关乳酸性酸中毒（MALA）是一种罕见病症（约每年每100,000例患者中有10例），但仍不断有新病例被报道，死亡率为40%-50%。我们描述了两例以严重代谢性酸中毒、高乳酸血症和急性肾损伤为特征的临床病例。第一例还合并非ST段抬高型心肌梗死，经成功治疗。
