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不同姑息治疗模式对接受维持性透析的肾衰竭死亡患者的影响:台湾一项基于全国人口的回顾性观察研究。

Effects of different palliative care models on decedents with kidney failure receiving maintenance dialysis: a nationwide population-based retrospective observational study in Taiwan.

机构信息

Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.

出版信息

BMJ Open. 2023 Jul 10;13(7):e069835. doi: 10.1136/bmjopen-2022-069835.

Abstract

OBJECTIVES

Patients with kidney failure receiving maintenance dialysis are a particularly important population and carry a heavy disease burden. However, evidence related to palliative care for patients with kidney failure receiving maintenance dialysis remains scarce, especially in regard to palliative care consultation services and palliative home care. This study aimed to evaluate the effects of different palliative care models on aggressive treatment among patients with kidney failure receiving maintenance dialysis during the end of life.

DESIGN

A population-based retrospective observational study.

SETTING

This study used a population database maintained by Taiwan's Ministry of Health and Welfare in combination with Taiwan's National Health Research Insurance Database.

PARTICIPANTS

We enrolled all decedents who were patients with kidney failure receiving maintenance dialysis from the period 1 January 2017 to 31 December 2017 in Taiwan.

MAIN EXPOSURE MEASURE

Hospice care during the 1-year period before death.

MAIN OUTCOME MEASURES

Eight aggressive treatments within 30 days before death, more than one emergency department visit, more than one admission, a longer than 14-day admission, admission to an intensive care unit, death in hospital, endotracheal tube use, ventilator use and need for cardiopulmonary resuscitation.

RESULTS

A total of 10 083 patients were enrolled, including 1786 (17.7%) patients with kidney failure who received palliative care 1 year before death. Compared with patients without palliative care, patients with palliative care had significantly less aggressive treatments within 30 days before death (Estimates: -0.09, CI: -0.10 to -0.08). Patients with inpatient palliative care, palliative home care or a mixed model experienced significantly lower treatment aggressiveness within 30 days before death.

CONCLUSIONS

Palliative care, particularly use of a mixed care model, inpatient palliative care and palliative home care in patients with kidney failure receiving dialysis, could all significantly reduce the aggressiveness of treatment within 30 days before death.

摘要

目的

接受维持性透析的肾衰竭患者是一个特别重要的群体,他们承受着沉重的疾病负担。然而,有关接受维持性透析的肾衰竭患者的姑息治疗的证据仍然很少,特别是在姑息治疗咨询服务和姑息性家庭护理方面。本研究旨在评估不同姑息治疗模式对终末期接受维持性透析的肾衰竭患者的侵袭性治疗的影响。

设计

基于人群的回顾性观察性研究。

设置

本研究使用了台湾卫生福利部维护的一个人群数据库,并结合了台湾全民健康保险数据库。

参与者

我们纳入了 2017 年 1 月 1 日至 2017 年 12 月 31 日期间在台湾接受维持性透析的所有死亡患者。

主要暴露措施

死亡前 1 年的临终关怀。

主要观察指标

死亡前 30 天内的 8 种侵袭性治疗、1 次以上急诊就诊、1 次以上住院、住院时间超过 14 天、入住重症监护病房、院内死亡、使用气管内插管、使用呼吸机和需要心肺复苏。

结果

共纳入 10083 例患者,其中 1786 例(17.7%)肾衰竭患者在死亡前 1 年接受姑息治疗。与未接受姑息治疗的患者相比,接受姑息治疗的患者在死亡前 30 天内的侵袭性治疗明显减少(估计值:-0.09,CI:-0.10 至-0.08)。接受住院姑息治疗、姑息性家庭护理或混合模式治疗的患者在死亡前 30 天内的治疗侵袭性明显降低。

结论

姑息治疗,特别是在接受透析治疗的肾衰竭患者中使用混合治疗模式、住院姑息治疗和姑息性家庭护理,都可以显著降低死亡前 30 天内的治疗侵袭性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24c2/10335480/1eaf9a615747/bmjopen-2022-069835f01.jpg

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