Clin Nephrol. 2021 Jul;96(1):22-28. doi: 10.5414/CN110096.
The majority of dialysis patients receive aggressive burdensome treatment near the end of life. Currently, we lack interventions to improve end-of-life care (EoLC) for these patients. We examined the association of palliative care consultation with improving EoLC for critically ill patients with end-stage renal disease (ESRD) who received cardiopulmonary resuscitation (CPR).
In this retrospective study, we included patients with ESRD admitted to a large academic center who received CPR either prior to or during their hospital stay. Over 8 years, 17 out of 403 patients received palliative care consultation during their hospital stay; consultations were not standardized in their content. Main outcomes of interest to operationalize better EoLC were: (1) change in code status from full code to do not resuscitate (DNR) and (2) withdrawal from intensive care.
Of the patients studied, 60.5% were African-American and 43.2% were female. Demographic differences between those with palliative care consultation and those with usual care were not statistically significant. Palliative care consultation was associated with higher odds of change in code status to DNR (odds ratio 8.10, 95% confidence interval 2.19 - 29.94) and withdrawal from intensive care (odds ratio 8.82, 95% confidence interval 2.69 - 28.91) in patients with ESRD who had received CPR. Palliative care consultation was not associated with any change in in-hospital mortality.
Palliative care consultation needs to be considered for hospitalized ESRD patients with limited expected prognoses as it may reduce aggressive and burdensome therapies at the end of life. Furthermore, primary palliative care skills such as communication and decision-making should be taught to nephrologists to improve EoLC for dialysis patients.
大多数透析患者在生命末期接受积极的治疗。目前,我们缺乏改善这些患者生命终末期护理(EoLC)的干预措施。我们研究了姑息治疗咨询与接受心肺复苏(CPR)的终末期肾病(ESRD)危重症患者 EoLC 改善之间的关系。
在这项回顾性研究中,我们纳入了在大型学术中心住院并接受 CPR 的 ESRD 患者。在 8 年期间,有 17 名患者在住院期间接受了姑息治疗咨询;咨询内容没有标准化。改善 EoLC 的操作主要结果包括:(1)从全面复苏改为不复苏(DNR)的代码状态变化和(2)从重症监护中撤出。
在所研究的患者中,60.5%为非裔美国人,43.2%为女性。有姑息治疗咨询和常规护理的患者之间的人口统计学差异无统计学意义。姑息治疗咨询与 ESRD 患者 CPR 后 DNR 代码状态改变的几率增加(优势比 8.10,95%置信区间 2.19 - 29.94)和从重症监护中撤出(优势比 8.82,95%置信区间 2.69 - 28.91)相关。姑息治疗咨询与住院期间死亡率无任何变化相关。
对于预期预后有限的住院 ESRD 患者,应考虑姑息治疗咨询,因为它可能会减少生命末期的积极和负担过重的治疗。此外,应向肾脏病学家传授沟通和决策等主要姑息治疗技能,以改善透析患者的 EoLC。