Graduate School, Hebei North University, Zhangjiakou City, Hebei Province, 075000, China.
Department of Respiratory & Critical Care Clinical Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, 075000, China.
Immunotherapy. 2023 Oct;15(14):1117-1123. doi: 10.2217/imt-2023-0006. Epub 2023 Jul 11.
Immune checkpoint inhibitor (ICI)-related chronic pneumonitis is rare. Limited information is available on the characteristics of this condition. Herein, we present the case of a 54-year-old man with recurrent severe ICI-related pneumonitis. The patient developed fever and dyspnea during both episodes of pneumonitis. He had been previously diagnosed with gastric signet ring cell carcinoma and was undergoing treatment with an anti-PD-1 combination chemotherapy regimen. We reviewed previous case reports of ICI-related pneumonitis according to the primary cancer, time of onset in relation to ICI therapy and chest imaging findings. ICI-related pneumonitis can progress to chronic pneumonitis. Repeated computed tomography imaging showing lung changes in the same location may help to make the diagnosis.
免疫检查点抑制剂（ICI）相关的慢性肺炎罕见。关于这种疾病的特征，信息有限。在此，我们报告了一例 54 岁男性患者，他患有复发性严重 ICI 相关肺炎。患者在两次肺炎发作期间均出现发热和呼吸困难。他之前被诊断为胃印戒细胞癌，并正在接受抗 PD-1 联合化疗。我们根据原发癌、与 ICI 治疗的时间关系和胸部影像学表现，对 ICI 相关肺炎的既往病例报告进行了回顾。ICI 相关肺炎可进展为慢性肺炎。反复的 CT 成像显示同一部位的肺部变化有助于做出诊断。
