School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Department of Rehabilitation Medicine, Huanggang Central Hospital, Huanggang, China.
Physiology (Bethesda). 2023 Nov 1;38(6):0. doi: 10.1152/physiol.00013.2023. Epub 2023 Jul 11.
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide that poses a significant threat to human health. Cardiovascular disease (CVD) is the leading cause of mortality in NAFLD patients. NAFLD and CVD share risk factors such as obesity, insulin resistance, and type 2 diabetes. However, whether NAFLD is a causal risk factor for CVD remains a matter of debate. This review summarizes the evidence from prospective clinical and Mendelian randomization studies that underscore the potential causal relationship between NAFLD and CVD. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病，对人类健康构成重大威胁。心血管疾病（CVD）是 NAFLD 患者死亡的主要原因。NAFLD 和 CVD 具有共同的危险因素，如肥胖、胰岛素抵抗和 2 型糖尿病。然而，NAFLD 是否是 CVD 的因果危险因素仍存在争议。本综述总结了前瞻性临床和孟德尔随机化研究的证据，强调了 NAFLD 与 CVD 之间存在潜在的因果关系。还讨论了 NAFLD 导致 CVD 发展的机制，以及在临床实践中管理 NAFLD 时需要同时考虑 CVD 风险的必要性。
