抗生素X-14547A的分离与鉴定，这是一种由抗生链霉菌NRRL 8167产生的新型单羧酸离子载体。
Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167.
作者信息
Westley J W, Evans R H, Sello L H, Troupe N, Liu C M, Blount J F
出版信息
J Antibiot (Tokyo). 1979 Feb;32(2):100-7. doi: 10.7164/antibiotics.32.100.
A novel carboxylic acid ionophore, antibiotic X-14547A, closely related to the polyether antibiotics has been isolated along with four other metabolites from fermented cultures of a new strain of Streptomyces antibioticus. The structure, determined by X-ray analysis of the R(+)-1-amino-1-(4-bromophenyl)-ethane salt contained pyrrole carbonyl and trans-butadienyl chromophores in addition to the unusual tetrahydroindane bicyclic ring system. A second novel metabolite was identified as 3-ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one.
一种新型羧酸离子载体抗生素X-14547A，与聚醚类抗生素密切相关，已与其他四种代谢产物一起从一株新的抗生链霉菌发酵培养物中分离出来。通过对R(+)-1-氨基-1-(4-溴苯基)-乙烷盐进行X射线分析确定其结构，除了不寻常的四氢茚双环系统外，还含有吡咯羰基和反式丁二烯基发色团。另一种新型代谢产物被鉴定为3-乙基-1,3-二氢-3-甲氧基-2H-吲哚-2-酮。
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