Westley J W, Liu C M, Blount J F, Todaro L, Sello L H, Troupe N
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110.
J Antibiot (Tokyo). 1993 Feb;46(2):280-6. doi: 10.7164/antibiotics.46.280.
Streptomyces sp. X-14889 (NRRL 15517) has been found to produce a number of novel polyether antibiotics and an orange pigment. One of the antibiotics, X-14889B (3) was identified as ferensimycin A, which in turn is an isomer of the well-studied polyether antibiotic, lysocellin (1). Of the three other antibiotics, X-14889C (4) is a lower homolog of ferensimycin A and antibiotics X-14889A (2) and D (5) which are respectively the descarboxy and anhydro-descarboxy forms of this same molecule. The latter compound, X-14889D is of interest as it contains an ether bridge across the terminal tetrahydrofuranyl ring in an analogous relationship to that reported earlier for antibiotics X-14873A (6) and G.
链霉菌属X - 14889（NRRL 15517）已被发现能产生多种新型聚醚抗生素和一种橙色色素。其中一种抗生素，X - 14889B（3）被鉴定为费伦西霉素A，而费伦西霉素A又是经过充分研究的聚醚抗生素溶胞菌素（1）的异构体。在其他三种抗生素中，X - 14889C（4）是费伦西霉素A的低级同系物，抗生素X - 14889A（2）和D（5）分别是同一分子的脱羧形式和脱水脱羧形式。后一种化合物，X - 14889D很有趣，因为它在末端四氢呋喃环上含有一个醚桥，其结构与先前报道的抗生素X - 14873A（6）和G类似。
