Department of Pathology, Division of Cytopatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Cir Cir. 2023;91(3):319-325. doi: 10.24875/CIRU.22000400.
The aim of this study was to investigate the prevalence, genotype, and distribution of cervical human papillomavirus (HPV) in women living in southeast Turkey.
A total of 13,300 cervical smear materials were scanned and 899 cases found to be HPV-positive were included in the study. Cases were divided into seven groups according to age (under 19 years of age, 20-24, 25-29, 30-39, 40-49, 50-59, and over 60 years old) and six groups according to HPV types (HPV type 16, HPV type 18, HPV type 16-18 association, HPV type 16-high risk (HR) association, HPV Type 18-HR association, and HPV HR [31,33,35,39,45, 51,52,56,58,59,66, and 68]). SurePath liquid-based cytology preparations were evaluated, and HPV tests were performed using real-time-polymerase chain reaction.
A total of 6.7% of cervical smear samples were positive for HPV DNA. The mean age of these cases was 41 years (range 15-78 years). All HPV types showed the highest rate of positivity in the 30-39 age groups. Regarding the distribution of HPV types, most of the cases were in the HPV HR group (66%). The most common atypia category detected in cytological examination was "Atypical squamous cells of undetermined significance" (ASC-US) (27%).
It was determined that the prevalence of HPV in the southeast of Turkey is lower than the world average, the most common HPV type in our region is HPV-HR, and HPV peaks at older ages compared to what has been reported for other regions of the world.
本研究旨在调查土耳其东南部地区女性宫颈人乳头瘤病毒（HPV）的流行率、基因型和分布。
共扫描了 13300 份宫颈涂片标本，发现 899 例 HPV 阳性病例纳入研究。根据年龄（19 岁以下、20-24 岁、25-29 岁、30-39 岁、40-49 岁、50-59 岁和 60 岁以上）和 HPV 类型（HPV 16 型、HPV 18 型、HPV 16-18 型联合感染、HPV 16-高危型（HR）型联合感染、HPV 18-HR 型联合感染和 HPV HR 型[31、33、35、39、45、51、52、56、58、59、66 和 68]）将病例分为七组和六组。采用液基细胞学 SurePath 制片进行评估，并采用实时聚合酶链反应（PCR）进行 HPV 检测。
共 6.7%的宫颈涂片样本 HPV DNA 阳性。这些病例的平均年龄为 41 岁（15-78 岁）。所有 HPV 类型在 30-39 岁年龄组的阳性率最高。关于 HPV 类型的分布，大多数病例属于 HPV HR 组（66%）。细胞学检查中最常见的不典型类别为“非典型鳞状细胞意义不明确”（ASC-US）（27%）。
确定土耳其东南部地区 HPV 的流行率低于世界平均水平，本地区最常见的 HPV 类型是 HPV-HR，与世界其他地区报道的情况相比，HPV 发病高峰出现在较晚的年龄。
