Fan X J, Xie J G, Lin P Z, Cui W, Zhang J S, Shen H, Ha X W, Okada M
Zhonghua Zhong Liu Za Zhi. 1986 May;8(3):181-3.
PDT of rat bladder cancer, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was studied. All animals were divided at random into three groups. Group 2 and 3 were treated by hematoporphyrin derivative (HPD)-laser PDT while group 1, without treatment, served as control. The results showed that the malignant lesions could be selectively and obviously destroyed, if the whole tumor area were sufficiently exposed to the laser irradiation. However, the normal bladder epithelium and muscle layer showed no histologic change. Similar reactions were found in papilloma of bladder which was considered as precancerous lesion. Thus, PDT may be beneficial to cancer prevention. Its role in prevention and treatment of bladder cancer should be further studied experimentally and clinically.
研究了由N-丁基-N-(4-羟丁基)亚硝胺（BBN）诱导的大鼠膀胱癌的光动力疗法（PDT）。所有动物随机分为三组。第2组和第3组接受血卟啉衍生物（HPD）-激光光动力疗法治疗，而第1组未接受治疗作为对照。结果表明，如果整个肿瘤区域充分暴露于激光照射下，恶性病变可被选择性且明显地破坏。然而，正常膀胱上皮和肌肉层未显示组织学变化。在被视为癌前病变的膀胱乳头状瘤中也发现了类似反应。因此，光动力疗法可能对癌症预防有益。其在膀胱癌预防和治疗中的作用应进一步进行实验和临床研究。
