[Effect of cis-diamminedichloroplatinum (II) (CDDP) on bladder cancer on rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)].

The effect of CDDP was studied on rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). A total of 140 rats was divided into 7 groups and 0.05% BBN in drinking water was given for 8 weeks. Half doses of LD50 of CDDP, mitomycin C, cyclophosphamide were injected to rats at the 16th or 20th experimental week. All rats were sacrificed at the end of 24 weeks and bladders were removed. Each of the groups receiving anticancer drugs had significant reduction in mean tumor number per rat compared to the control group (p less than 0.05). CDDP was the most effective in reducing tumor size when it was administered at the 16th week (p less than 0.01).