顺二氯二氨铂（II）（CDDP）对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）诱导的大鼠膀胱癌的影响
[Effect of cis-diamminedichloroplatinum (II) (CDDP) on bladder cancer on rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)].
作者信息
Miyakawa M, Yoshida O
出版信息
Gan To Kagaku Ryoho. 1982 Feb;9(2):258-62.
The effect of CDDP was studied on rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). A total of 140 rats was divided into 7 groups and 0.05% BBN in drinking water was given for 8 weeks. Half doses of LD50 of CDDP, mitomycin C, cyclophosphamide were injected to rats at the 16th or 20th experimental week. All rats were sacrificed at the end of 24 weeks and bladders were removed. Each of the groups receiving anticancer drugs had significant reduction in mean tumor number per rat compared to the control group (p less than 0.05). CDDP was the most effective in reducing tumor size when it was administered at the 16th week (p less than 0.01).
研究了顺铂（CDDP）对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）诱导的大鼠膀胱肿瘤的作用。总共140只大鼠被分为7组，给予0.05%的BBN饮水8周。在实验第16周或第20周，将顺铂、丝裂霉素C、环磷酰胺半数致死量的剂量注射给大鼠。在24周结束时处死所有大鼠并取出膀胱。与对照组相比，接受抗癌药物治疗的每组大鼠的平均肿瘤数量均显著减少（p<0.05）。当在第16周给予顺铂时，其在减小肿瘤大小方面最有效（p<0.01）。
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