Potter J M, Green A, Cullen D R, Milner R D
Diabetes Res Clin Pract. 1986 Jun;2(3):123-6. doi: 10.1016/s0168-8227(86)80012-2.
Plasma amino acid concentrations were measured in six insulin-dependent diabetic women and seven non-diabetic women in early pregnancy while fasting and one hour after a standard meal. Fasting plasma levels of total amino acids and individual amino acids were similar in the two groups, excepting isoleucine, which was raised in the diabetics. One hour post-prandially total amino acid concentrations were similar in the two groups; however, mean concentrations of total branched chain amino acids and mean concentration of the individual amino acids, serine, valine, isoleucine, leucine and tyrosine were elevated in the diabetics. Amino acids are important in early islet development and in insulin secretion from fetal pancreas in vitro. The elevated post-prandial amino acid levels found in pregnant diabetics in early pregnancy may contribute to fetal islet hypertrophy and hyperinsulinaemia.
对6名胰岛素依赖型糖尿病孕妇和7名非糖尿病孕妇在妊娠早期空腹时以及标准餐后1小时测量了血浆氨基酸浓度。两组的空腹血浆总氨基酸和单个氨基酸水平相似，但异亮氨酸除外，糖尿病患者的异亮氨酸水平升高。餐后1小时，两组的总氨基酸浓度相似；然而，糖尿病患者的总支链氨基酸平均浓度以及单个氨基酸丝氨酸、缬氨酸、异亮氨酸、亮氨酸和酪氨酸的平均浓度升高。氨基酸在早期胰岛发育和体外胎儿胰腺胰岛素分泌中很重要。妊娠早期糖尿病孕妇餐后氨基酸水平升高可能导致胎儿胰岛肥大和高胰岛素血症。
