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在与交感神经节和肌肉细胞共培养时，脊髓神经元的突触形成及乙酰胆碱受体的诱导。

Synapse formation and induction of acetylcholine receptors by spinal neurones in cocultures with sympathetic ganglion and muscle cells.

作者信息

Leah J D, Gipps E, Kidson C

出版信息

Dev Neurosci. 1986;8(2):76-88. doi: 10.1159/000112243.

DOI:10.1159/000112243
PMID:3743471
Abstract

Coculture of chick embryonic sympathetic neurones with spinal cord explants induced an age-dependent increase in the acetylcholine receptor numbers of the ganglion cells. These acetylcholine receptors did not appear to be necessary for the initial formation of spinal cord-ganglion synapses since their blockade with the alpha-bungarotoxin-horseradish peroxidase complex did not prevent synapse formation in culture. The presence of acetylcholine receptors appears to be sufficient for synapse formation since inappropriate motoneurone-ganglion synapses could form and were stable.

摘要

鸡胚交感神经元与脊髓外植体共培养导致神经节细胞乙酰胆碱受体数量呈年龄依赖性增加。这些乙酰胆碱受体对于脊髓-神经节突触的初始形成似乎并非必需，因为用α-银环蛇毒素-辣根过氧化物酶复合物阻断它们并不会阻止培养物中突触的形成。乙酰胆碱受体的存在似乎足以形成突触，因为不适当的运动神经元-神经节突触能够形成且稳定。

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Synapse formation and induction of acetylcholine receptors by spinal neurones in cocultures with sympathetic ganglion and muscle cells.在与交感神经节和肌肉细胞共培养时，脊髓神经元的突触形成及乙酰胆碱受体的诱导。
Dev Neurosci. 1986;8(2):76-88. doi: 10.1159/000112243.
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引用本文的文献

1
Neural regulation of acetylcholine sensitivity in embryonic sympathetic neurons.胚胎交感神经元中乙酰胆碱敏感性的神经调节
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2825-9. doi: 10.1073/pnas.85.8.2825.