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从脑和脊髓中提取的一种因子对培养的骨骼肌上乙酰胆碱受体的诱导作用。

Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord.

作者信息

Jessell T M, Siegel R E, Fischbach G D

出版信息

Proc Natl Acad Sci U S A. 1979 Oct;76(10):5397-401. doi: 10.1073/pnas.76.10.5397.

DOI:10.1073/pnas.76.10.5397
PMID:291956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC413150/
Abstract

Extracts of chicken brain and spinal cord increase the total number of acetylcholine receptors and the number of acetylcholine receptors and the number of receptor clusters on uninnervated skeletal myotubes in culture. The active component in these extracts may be unique to neural tissue. Spinal cord cells grown in culture contain the active factor and they secrete it into the medium. Most of the activity is associated with a small molecule possibly a peptide. Such a factor may be responsible for the clustering of receptors at newly formed nerve-muscle synapses.

摘要

鸡脑和脊髓提取物可增加培养中未受神经支配的骨骼肌肌管上乙酰胆碱受体的总数、乙酰胆碱受体数量以及受体簇的数量。这些提取物中的活性成分可能是神经组织所特有的。培养的脊髓细胞含有这种活性因子并将其分泌到培养基中。大部分活性与一种可能是肽的小分子有关。这样一种因子可能负责新形成的神经 - 肌肉突触处受体的聚集。

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1
Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord.从脑和脊髓中提取的一种因子对培养的骨骼肌上乙酰胆碱受体的诱导作用。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5397-401. doi: 10.1073/pnas.76.10.5397.
2
Extracts of electric lobe and electric organ from Torpedo californica increase the total number as well as the number of aggregates of chick myotube acetylcholine receptors.加州电鳐的电叶和电器官提取物增加了鸡肌管乙酰胆碱受体的总数以及聚集体的数量。
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Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells.神经提取物可诱导克隆肌肉细胞上乙酰胆碱受体数量增加并重新分布。
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