Hirsch Suzanna, Rosen Rachel
Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology & Nutrition, Boston Children's Hospital, Boston, MA.
J Clin Gastroenterol. 2023 Sep 1;57(8):754-759. doi: 10.1097/MCG.0000000000001868.
Gastroesophageal reflux (GER) is one of the most common presenting complaints to pediatric gastroenterologists, and a wide variety of symptoms in children are potentially attributable to typical or atypical GER. While reflux diagnosis and treatment paradigms classically have focused on targeting acid, there is a growing recognition of the prevalence and significance of nonacid GER in both children and adults. This review explores the role of nonacid reflux in pediatric patients, including definitions, associations with symptoms, pathophysiologic mechanisms, and treatment implications.
胃食管反流（GER）是儿科胃肠病学家最常遇到的主诉之一，儿童的多种症状都可能归因于典型或非典型GER。虽然反流的诊断和治疗模式传统上侧重于针对胃酸，但人们越来越认识到非酸性GER在儿童和成人中的患病率及其重要性。本综述探讨了非酸性反流在儿科患者中的作用，包括定义、与症状的关联、病理生理机制以及对治疗的影响。
