Lacombe Research and Development Centre, Agriculture and Agri-Food Canada, Lacombe, AB, Canada; Department of Food and Human Nutritional Science, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB, Canada.
Department of Animal Science, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB, Canada.
Meat Sci. 2023 Oct;204:109274. doi: 10.1016/j.meatsci.2023.109274. Epub 2023 Jul 4.
This study identified genomic variants and underlying candidate genes related to the whole carcass and individual primal cut lean content in Canadian commercial crossbred beef cattle. Genotyping information of 1035 crossbred beef cattle were available alongside estimated and actual carcass lean meat yield and individual primal cut lean content in all carcasses. Significant fixed effects and covariates were identified and included in the animal model. Genome-wide association analysis were implemented using the weighted single-step genomic best linear unbiased prediction (WssGBLUP). A number of candidate genes identified linked to lean tissue production were unrelated to estimated lean meat yield and were specific to the actual lean traits. Among these, 41 genes were common for actual lean traits, on specific regions of BTA4, BTA13 and BTA25 indicating potential involvement in lean mass synthesis. Therefore, the results suggested the inclusion of primal cut lean traits as a selection objective in breeding programs with consideration of further functional studies of the identified genes could help in optimizing lean yield for maximal carcass value.
本研究鉴定了与加拿大商业杂交肉牛全胴体和单个初级切块瘦肉含量相关的基因组变异和潜在候选基因。在所有胴体中，提供了 1035 头杂交肉牛的基因分型信息以及估计和实际胴体瘦肉产量和单个初级切块瘦肉含量。确定了显著的固定效应和协变量，并将其包含在动物模型中。使用加权单步基因组最佳线性无偏预测（WssGBLUP）进行全基因组关联分析。鉴定出与瘦肉组织生产相关的一些候选基因与估计的瘦肉产量无关，并且与实际的瘦肉性状特异性相关。其中，41 个基因在特定的 BTA4、BTA13 和 BTA25 区域上与实际的瘦肉性状共有，表明它们可能参与了瘦肉质量的合成。因此，结果表明，在选育计划中应将初级切块瘦肉性状作为一个选择目标，考虑对鉴定基因进行进一步的功能研究，有助于优化瘦肉产量以获得最大的胴体价值。
