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牛基因组学近期技术发展概述。

An overview of recent technological developments in bovine genomics.

作者信息

Ghavi Hossein-Zadeh Navid

机构信息

Department of Animal Science, Faculty of Agricultural Sciences, University of Guilan, Rasht, 41635-1314, Iran.

出版信息

Vet Anim Sci. 2024 Jul 23;25:100382. doi: 10.1016/j.vas.2024.100382. eCollection 2024 Sep.

Abstract

Cattle are regarded as highly valuable animals because of their milk, beef, dung, fur, and ability to draft. The scientific community has tried a number of strategies to improve the genetic makeup of bovine germplasm. To ensure higher returns for the dairy and beef industries, researchers face their greatest challenge in improving commercially important traits. One of the biggest developments in the last few decades in the creation of instruments for cattle genetic improvement is the discovery of the genome. Breeding livestock is being revolutionized by genomic selection made possible by the availability of medium- and high-density single nucleotide polymorphism (SNP) arrays coupled with sophisticated statistical techniques. It is becoming easier to access high-dimensional genomic data in cattle. Continuously declining genotyping costs and an increase in services that use genomic data to increase return on investment have both made a significant contribution to this. The field of genomics has come a long way thanks to groundbreaking discoveries such as radiation-hybrid mapping, in situ hybridization, synteny analysis, somatic cell genetics, cytogenetic maps, molecular markers, association studies for quantitative trait loci, high-throughput SNP genotyping, whole-genome shotgun sequencing to whole-genome mapping, and genome editing. These advancements have had a significant positive impact on the field of cattle genomics. This manuscript aimed to review recent advances in genomic technologies for cattle breeding and future prospects in this field.

摘要

牛因其产奶、产肉、产粪、产毛以及具备役用能力而被视为极具价值的动物。科学界已尝试多种策略来改善牛种质的基因构成。为确保乳制品和牛肉行业获得更高回报,研究人员在改善具有商业重要性的性状方面面临着最大挑战。在过去几十年里,牛基因改良工具的最大进展之一就是基因组的发现。基因组选择借助中高密度单核苷酸多态性(SNP)阵列以及先进的统计技术得以实现,这正在彻底改变家畜育种方式。获取牛的高维基因组数据正变得愈发容易。基因分型成本持续下降,以及利用基因组数据提高投资回报率的服务增加,都对此做出了重大贡献。得益于诸如辐射杂种图谱绘制、原位杂交、同线性分析、体细胞遗传学、细胞遗传图谱、分子标记、数量性状位点关联研究、高通量SNP基因分型、全基因组鸟枪法测序到全基因组图谱绘制以及基因组编辑等开创性发现,基因组学领域取得了长足进展。这些进展对牛基因组学领域产生了重大积极影响。本手稿旨在综述牛育种基因组技术的最新进展以及该领域的未来前景。

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An overview of recent technological developments in bovine genomics.牛基因组学近期技术发展概述。
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Outlook on genome editing application to cattle.牛基因组编辑应用展望。
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