Lu Wubing, Li Zhi, Shi Shanjun, Meng Sicen, Pang Jieru, Li Yan, Li Mingcai
Department of Immunology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Department of Clinical Laboratory, Ningbo No. 6 Hospital Affiliated to Ningbo University, Ningbo, China.
Future Sci OA. 2025 Dec;11(1):2545732. doi: 10.1080/20565623.2025.2545732. Epub 2025 Aug 18.
Interleukin (IL)-41 is a novel cytokine, also known as Metrnl, and its role in ankylosing spondylitis (AS) remains unknown. The aim of this study is to measure the serum IL-41 levels in AS patients and their correlation with other clinical indicators.
This study recruited 106 participants, including 32 active AS patients, 32 inactive AS patients, and 42 healthy controls (HC). Basic information and clinical indicators of participants were obtained through physical examination and blood sample testing. Enzyme-linked immunosorbent assay was used to detect IL-41 levels.
Patients with active and inactive AS had significantly higher serum IL-41 levels than HC. Moreover, correlation analysis showed that IL-41 in active AS was positively correlated with lymphocyte percentage; IL-41 in inactivated AS is negatively correlated with alkaline phosphatase and creatinine. IL-41 as an independent protective factor for AS had good value for the diagnosis of AS.
This study indicates that serum IL-41 levels are elevated in both active and inactive AS patients, suggesting that IL-41 may be a novel biomarker for AS.
白细胞介素（IL）-41是一种新型细胞因子，也被称为Metrnl，其在强直性脊柱炎（AS）中的作用尚不清楚。本研究旨在测量AS患者的血清IL-41水平及其与其他临床指标的相关性。
本研究招募了106名参与者，包括32名活动期AS患者、32名非活动期AS患者和42名健康对照（HC）。通过体格检查和血液样本检测获取参与者的基本信息和临床指标。采用酶联免疫吸附测定法检测IL-41水平。
活动期和非活动期AS患者的血清IL-41水平均显著高于HC。此外，相关性分析显示，活动期AS患者的IL-41与淋巴细胞百分比呈正相关；非活动期AS患者的IL-41与碱性磷酸酶和肌酐呈负相关。IL-41作为AS的独立保护因子，对AS的诊断具有良好价值。
本研究表明，活动期和非活动期AS患者的血清IL-41水平均升高，提示IL-41可能是AS的一种新型生物标志物。
