Elmslie R E, Glawe P, Dow S W
Veterinary Cancer Specialists, Englewood, CO, USA.
J Vet Intern Med. 2008 Nov-Dec;22(6):1373-9. doi: 10.1111/j.1939-1676.2008.0179.x. Epub 2008 Oct 3.
Continuous administration of low doses of cyclophosphamide and standard doses of cyclooxygenase-inhibiting drugs has been shown to suppress tumor angiogenesis, reverse immunosuppression, and deplete regulatory T cells in cancer models.
We hypothesized that continuous treatment with low-dose cyclophosphamide and full-dose piroxicam would delay tumor recurrence in dogs with soft tissue sarcomas (STS).
Eighty-five dogs with incompletely resected STS, 30 treated dogs, and 55 contemporary control dogs.
Treatment outcomes in 85 dogs with incompletely resected STS were evaluated in a retrospective study. Dogs in the treatment group received continuously administered low-dose cyclophosphamide (10 mg/m2) and standard dose piroxicam (0.3 mg/kg) therapy. Time to local tumor recurrence (disease-free interval; DFI) was compared between the 30 treated dogs and 55 untreated control dogs matched for age and tumor site and grade.
DFI was significantly (P < .0001) prolonged for STS of all sites (trunk and extremity) in treated dogs compared with untreated control dogs. The DFI also was significantly longer in treated dogs when tumor site (trunk and extremity) was compared. Twelve treated dogs (40%) experienced mild toxicity (grade 1 and 2) at some point during treatment and 1 dog developed grade 4 cystitis. Every other day dosing was tolerated better than daily dosing.
Metronomic therapy with cyclophosphamide and piroxicam was very effective in preventing tumor recurrence in dogs with incompletely resected STS. These findings suggest that further evaluation of this approach is warranted as adjuvant therapy in dogs with highly metastatic tumors such as osteosarcoma and melanoma.
在癌症模型中，持续给予低剂量环磷酰胺和标准剂量的环氧化酶抑制药物已显示可抑制肿瘤血管生成、逆转免疫抑制并消耗调节性T细胞。
我们假设持续用低剂量环磷酰胺和全剂量吡罗昔康治疗可延迟软组织肉瘤（STS）犬的肿瘤复发。
85只STS切除不完全的犬、30只接受治疗的犬和55只同期对照犬。
在一项回顾性研究中评估了85只STS切除不完全的犬的治疗结果。治疗组的犬接受持续给予的低剂量环磷酰胺（10mg/m²）和标准剂量吡罗昔康（0.3mg/kg）治疗。比较了30只接受治疗的犬和55只年龄、肿瘤部位和分级相匹配的未治疗对照犬的局部肿瘤复发时间（无病间隔期；DFI）。
与未治疗的对照犬相比，治疗犬所有部位（躯干和四肢）的STS的DFI显著延长（P <.0001）。当比较肿瘤部位（躯干和四肢）时，治疗犬的DFI也显著更长。12只治疗犬（40%）在治疗期间的某个时间点出现轻度毒性（1级和2级），1只犬发生4级膀胱炎。隔日给药比每日给药耐受性更好。
环磷酰胺和吡罗昔康的节拍式疗法在预防STS切除不完全的犬的肿瘤复发方面非常有效。这些发现表明，作为骨肉瘤和黑色素瘤等高转移性肿瘤犬的辅助治疗，有必要对这种方法进行进一步评估。
