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[衰弱表型与睡眠障碍的风险因素]

[Frailty phenotype and risk factor for disturbed sleep].

作者信息

Frohnhofen Helmut, Stenmanns Carla, Gronewold Janine, Mayer Geert

机构信息

Klinik für Orthopädie und Unfallchirurgie, Heinrich Heine Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Klinik für Neurologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

出版信息

Z Gerontol Geriatr. 2023 Nov;56(7):551-555. doi: 10.1007/s00391-023-02219-7. Epub 2023 Jul 12.

DOI:10.1007/s00391-023-02219-7
PMID:37438643
Abstract

Regardless of the nature of its operationalization, frailty has significant negative consequences for the person concerned and the community. Even if a generally accepted definition of frailty is still missing, there is no doubt about the existence of this phenomenon. Pathophysiologically, a dysfunctional interaction between multiple complex systems is discussed. Therapeutic interventions show that frailty is a dynamic state that can be improved. The pathophysiological characteristics of frailty and sleep disturbances show numerous similarities. In addition, the risk of frailty is increased in individuals with sleep disturbances. As the majority of sleep disorders can usually be well treated, screening for sleep disorders should be integrated into a comprehensive concept of management of frailty.

摘要

无论衰弱的操作化定义如何,它都会给相关个人和社区带来重大负面影响。尽管目前仍缺乏一个被普遍接受的衰弱定义,但这一现象的存在是毋庸置疑的。从病理生理学角度来看,人们讨论了多个复杂系统之间的功能失调性相互作用。治疗干预表明,衰弱是一种可以改善的动态状态。衰弱和睡眠障碍的病理生理特征有许多相似之处。此外,睡眠障碍患者发生衰弱的风险会增加。由于大多数睡眠障碍通常都能得到很好的治疗,因此睡眠障碍筛查应纳入衰弱综合管理概念中。

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本文引用的文献

1
The Safety and Efficacy of Concurrent Immune Checkpoint Blockade and Stereotactic Radiosurgery Therapy with Practitioner and Researcher Recommendations.同时使用免疫检查点阻断和立体定向放射外科治疗的安全性和有效性:从业者和研究人员的建议。
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The occurence of cancer in ageing populations at global and regional levels, 1990 to 2019.全球和区域老龄化人口中癌症的发生情况,1990 年至 2019 年。
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Prevalence and outcomes of frailty in unplanned hospital admissions: a systematic review and meta-analysis of hospital-wide and general (internal) medicine cohorts.
非计划住院患者中衰弱的患病率及结局:一项针对全院和普通(内科)医学队列的系统评价和荟萃分析
EClinicalMedicine. 2023 Apr 21;59:101947. doi: 10.1016/j.eclinm.2023.101947. eCollection 2023 May.
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The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data.用于预测老年急性入院重症监护患者死亡率的临床衰弱量表:个体患者水平数据的荟萃分析
Ann Intensive Care. 2023 May 3;13(1):37. doi: 10.1186/s13613-023-01132-x.
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Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study.维持健康的睡眠模式和虚弱状态的转变:一项前瞻性的中国研究。
BMC Med. 2022 Oct 21;20(1):354. doi: 10.1186/s12916-022-02557-0.
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The physical frailty syndrome as a transition from homeostatic symphony to cacophony.身体虚弱综合征是从体内平衡交响乐向不和谐音的转变。
Nat Aging. 2021 Jan;1(1):36-46. doi: 10.1038/s43587-020-00017-z. Epub 2021 Jan 14.
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Sleep duration and incident frailty: The Rural Frailty Study.睡眠时间与虚弱发生:农村虚弱研究。
BMC Geriatr. 2021 Jun 16;21(1):368. doi: 10.1186/s12877-021-02272-0.
8
Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems.来自两个队列的证据表明,脆弱综合征是一种多个生理系统平行失调的新兴状态。
Biogerontology. 2021 Feb;22(1):63-79. doi: 10.1007/s10522-020-09903-w. Epub 2020 Oct 16.
9
Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis.全球社区居住的老年人群中衰弱和衰弱前期的发病率:系统评价和荟萃分析。
JAMA Netw Open. 2019 Aug 2;2(8):e198398. doi: 10.1001/jamanetworkopen.2019.8398.
10
FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults.FRAILTOOLS 研究方案:全面验证虚弱评估工具,以在不同临床和社会环境中筛查和诊断虚弱,并为老年人的综合护理提供工具。
BMC Geriatr. 2019 Mar 18;19(1):86. doi: 10.1186/s12877-019-1042-1.