Terrosu P, Ibba G V, Franceschino V, Contini G M, Delpini A
G Ital Cardiol. 1986 Apr;16(4):321-7.
This study was undertaken to evaluate the effects of intravenous Propafenone (2 mg/kg over 5') on Left Ventricular (LV) function and coronary blood flow. Twelve patients with coronary artery disease and post-ischemic LV disfunction were examined during routine cardiac catheterization. Serial measurements of central hemodynamics, LV high-fidelity pressure and coronary blood flow were recorded at rest and every 10' after Propafenone administration. Heart rate was unchanged, suggesting that Propafenone did not affect sympathetic tone. Cardiac index slightly decreased (from 3.3 +/- 0.9 L/min/m2 to 3.1 +/- 0.6 L/min/m2 at 10', p = ns), LV end-diastolic pressure rose significantly (from 17.7 +/- 2.1 mmHg to 22.7 +/- 4.2 mmHg at 20', p less than 0.01) and dP/dt max fell from 1897 +/- 291 mmHg/sec to 1577 +/- 312 mmHg/sec (p less than 0.02). Systemic vascular resistances had only minimal changes. Concomitantly, coronary vascular resistances decreased (from 0.77 +/- 0.17 mmHg/ml/min to 0.61 +/- 0.12 mmHg/ml/min, p less than 0.02) and coronary blood flow increased (from 138 +/- 29 ml/min to 172 +/- 21 ml/min, p less than 0.01). No significant difference was noted in myocardial oxygen consumption. No symptoms related to LV failure were observed during the study. In conclusion hemodynamic effects of Propafenone are characterized by moderate LV depression and by coronary artery dilatation, probably due to a calcium blocker-like activity.
本研究旨在评估静脉注射普罗帕酮（5分钟内注射2mg/kg）对左心室（LV）功能和冠状动脉血流的影响。在常规心脏导管插入术期间，对12例患有冠状动脉疾病和缺血后左心室功能障碍的患者进行了检查。在静息状态下以及注射普罗帕酮后每隔10分钟记录一次中心血流动力学、左心室高保真压力和冠状动脉血流的系列测量值。心率未发生变化，表明普罗帕酮不影响交感神经张力。心脏指数略有下降（10分钟时从3.3±0.9L/min/m²降至3.1±0.6L/min/m²，p=无显著性差异），左心室舒张末期压力显著升高（20分钟时从17.7±2.1mmHg升至22.7±4.2mmHg，p<0.01），dp/dt max从1897±291mmHg/秒降至1577±312mmHg/秒（p<0.02）。全身血管阻力仅有微小变化。与此同时，冠状动脉血管阻力降低（从0.77±0.17mmHg/ml/min降至0.61±0.12mmHg/ml/min，p<0.02），冠状动脉血流增加（从138±29ml/min增至172±21ml/min，p<0.01）。心肌耗氧量未观察到显著差异。在研究期间未观察到与左心室衰竭相关的症状。总之，普罗帕酮的血流动力学效应的特征是左心室中度抑制和冠状动脉扩张，这可能归因于类似钙通道阻滞剂的活性。
