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成功的止血放射治疗感染性肺腔大气道出血:病例报告。

Successful hemostatic radiotherapy for massive airway bleeding from infectious pulmonary cavity: a case report.

机构信息

Department of Radiation Oncology, Zürich University Hospital, Zürich, Switzerland.

Department of Pulmonology, Zürich University Hospital, Zürich, Switzerland.

出版信息

Strahlenther Onkol. 2023 Sep;199(9):857-861. doi: 10.1007/s00066-023-02110-9. Epub 2023 Jul 13.

DOI:10.1007/s00066-023-02110-9
PMID:37439795
Abstract

We present a patient with life-threatening airway bleeding from an infectious pulmonary cavity with limited treatment options. Bronchial artery embolization was unsuccessful. Surgery was not feasible due to compromised lung function. Lung transplant was considered but not endorsed. Palliative hemostatic radiotherapy with 20 Gy in 5 fractions was delivered to the site of bleeding as a last resort. Hemoptysis gradually disappeared within a month and did not recur during the 4‑month follow-up. There were no side effects. We highlight the potential of radiotherapy for massive hemoptysis of infectious etiology, especially in cases with exhausted standard treatment options.

摘要

我们报告了一例患有具有致命威胁的气道出血的患者,该患者的肺部感染性空洞导致治疗选择有限。支气管动脉栓塞治疗失败。由于肺功能受损,手术不可行。考虑进行肺移植,但未得到认可。作为最后手段,对出血部位给予了 20Gy/5 次分割的姑息性止血放疗。咯血在一个月内逐渐消失,在 4 个月的随访中没有复发。没有出现副作用。我们强调了放疗对感染性病因引起的大咯血的潜在作用,尤其是在标准治疗方案已经用尽的情况下。

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本文引用的文献

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Stereotactic body radiotherapy for recurrent hemoptysis due to chronic pulmonary aspergillosis: a case report and systematic review of the literature.立体定向体部放疗治疗慢性肺部曲霉菌病所致复发性咯血:病例报告及文献系统评价。
Strahlenther Onkol. 2023 Feb;199(2):192-200. doi: 10.1007/s00066-022-02013-1. Epub 2022 Oct 20.
2
Linac-based stereotactic radiosurgery for brain arteriovenous malformations.基于直线加速器的立体定向放射外科治疗脑动静脉畸形。
Radiat Oncol. 2022 Sep 29;17(1):161. doi: 10.1186/s13014-022-02130-2.
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Tumour bleeding: Efficacy and outcome of haemostatic radiotherapy.
肿瘤出血:止血放疗的疗效和结果。
Natl Med J India. 2019 Nov-Dec;32(6):342-344. doi: 10.4103/0970-258X.303621.
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Aetiology, diagnosis and treatment of moderate-to-severe haemoptysis in a North American academic centre.北美学术中心中重度咯血的病因、诊断与治疗
ERJ Open Res. 2020 Oct 19;6(4). doi: 10.1183/23120541.00204-2020. eCollection 2020 Oct.
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Pulmonary aspergilloma: from classification to management.肺曲菌球:从分类到管理
Asian Cardiovasc Thorac Ann. 2020 Jan;28(1):33-38. doi: 10.1177/0218492319895113. Epub 2019 Dec 4.
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Managing Massive Hemoptysis.大咯血的处理
Chest. 2020 Jan;157(1):77-88. doi: 10.1016/j.chest.2019.07.012. Epub 2019 Jul 30.
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Observational, multicentre study on the epidemiology of haemoptysis.咯血流行病学的观察性多中心研究。
Eur Respir J. 2018 Jan 4;51(1). doi: 10.1183/13993003.01813-2017. Print 2018 Jan.
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Hemoptysis due to fungus ball after tuberculosis: A series of 21 cases treated with hemostatic radiotherapy.肺结核后曲菌球所致咯血:21例止血放疗治疗系列病例
BMC Infect Dis. 2015 Nov 26;15:546. doi: 10.1186/s12879-015-1288-y.
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Clinically significant bleeding in incurable cancer patients: effectiveness of hemostatic radiotherapy.无法治愈癌症患者的临床显著出血:止血放射治疗的效果。
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