Abatli Safaa, Hasan Mohammed, Sholi Suha B, Qashoo Ahmad, Maqboul Iyad
General Surgery, An-Najah National University Hospital, Nablus, PSE.
Plastic and Reconstructive Surgery, An-Najah National University Hospital, Nablus, PSE.
Cureus. 2023 Jun 11;15(6):e40247. doi: 10.7759/cureus.40247. eCollection 2023 Jun.
We describe a case of basal cell carcinoma (BCC) in a 36-year-old lady. She had a history of recurrent BCC in the ventral aspect of her right forearm. She presented to our hospital with her third recurrence of skin lesions in the same location. Histopathological examination of the skin revealed the features of BCC with evidence of perineural invasion (PNI). She underwent a margin-free, wide local excision, vacuum-assisted closure of the wound, and reconstructive surgery using a skin graft. She also underwent a sentinel lymph node biopsy (SLNB), which was negative for the tumor. Then she was referred for radiotherapy. Although the patient underwent a free-margin excision in the previous episodes, she came back years later with a recurrent lesion. It is considered that basal cell carcinomas larger than 3 cm in size with perineural invasion evidence on histopathological examination and with deep tissue involvement have a bad prognosis compared with the smaller superficial lesions. Thus, based on the findings in our case and the previously reported cases, careful follow-up is recommended for patients with BCC with bad prognostic factors. In certain high-risk cases, SLNB should be considered to rule out occult metastasis.
我们描述了一例36岁女性的基底细胞癌(BCC)病例。她有右前臂腹侧复发性基底细胞癌病史。她因同一部位皮肤病变第三次复发前来我院就诊。皮肤组织病理学检查显示基底细胞癌特征并有神经周围浸润(PNI)证据。她接受了无切缘的广泛局部切除、伤口负压封闭以及使用皮肤移植的重建手术。她还接受了前哨淋巴结活检(SLNB),结果显示肿瘤为阴性。然后她被转诊接受放疗。尽管该患者在之前的发作中接受了切缘阴性的切除,但多年后仍出现复发病变。据认为,组织病理学检查有神经周围浸润证据且累及深部组织的大于3 cm的基底细胞癌与较小的浅表病变相比预后较差。因此,根据我们病例及先前报道病例的结果,对于具有不良预后因素的基底细胞癌患者,建议进行密切随访。在某些高危病例中,应考虑进行前哨淋巴结活检以排除隐匿性转移。