肝细胞癌放射敏感性机制研究进展：综述
Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity: A comprehensive review.
作者信息
Yang Gaoyuan, Yan Huamei, Tang Yongchang, Yuan Feng, Cao Mingbo, Ren Yupeng, Li Yuxuan, He Zhiwei, Su Xiaorui, Yao Zhicheng, Deng Meihai
机构信息
Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Department of Radiation Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
出版信息
Chin J Cancer Res. 2023 Jun 30;35(3):266-282. doi: 10.21147/j.issn.1000-9604.2023.03.06.
Abstract
Primary liver cancer is a significant health problem worldwide. Hepatocellular carcinoma (HCC) is the main pathological type of primary liver cancer, accounting for 75%-85% of cases. In recent years, radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC. However, radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors. How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration. This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy, including epigenetics, transportation and metabolism, regulated cell death pathways, the microenvironment, and redox status, as well as the effect of nanoparticles on the radiosensitivity of liver cancer. It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy.
摘要
原发性肝癌是全球范围内一个重大的健康问题。肝细胞癌（HCC）是原发性肝癌的主要病理类型，占病例的75%-85%。近年来，放射治疗已成为肝癌的一种新兴治疗方法，对肝癌的各个阶段均有效。然而，肝癌细胞的放射敏感性对放射治疗的疗效有显著影响，且受多种因素调节。如何提高放射敏感性并改善放射治疗效果有待进一步探索。本综述总结了影响放射治疗敏感性机制的最新研究进展，包括表观遗传学、转运与代谢、调控性细胞死亡途径、微环境和氧化还原状态，以及纳米颗粒对肝癌放射敏感性的影响。期望能为肝癌放射治疗的临床治疗提供更有效的策略和方法。
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