Nikolaidou Eirini, Papadopoulou Sophia, Tzimorota Zoi, Pipinia Argiro, Stampou Panagiota, Karagergou Eleni
From the Department of Plastic, Reconstructive and Hand Surgery & Burn ICU, G. Papanikolaou General Hospital, Thessaloniki, Greece.
Plast Reconstr Surg Glob Open. 2023 Jul 11;11(7):e5101. doi: 10.1097/GOX.0000000000005101. eCollection 2023 Jul.
Pilomatrix carcinoma is an unusual and aggressive malignant tumor deriving from follicular matrix cells and exhibiting a metastatic potential to lungs and regional lymph nodes in 10% of cases. We report the case of a 54-year-old male patient who presented with a biopsy-proven malignant pilomatrixoma of the thoracic region, which recurred multiple times after previous excisions. Due to the size of the tumor (28 by 22 cm), wide excision and axillary lymphadenectomy of levels I and II were performed, followed by reconstruction with a free deep inferior epigastric artery perforator flap and adjuvant radiotherapy. Owing to its rarity, this tumor can initially be misdiagnosed, resulting in delayed treatment and recurrences if inadequately excised. Also, large tumor size is correlated with a higher incidence of metastasis. High index of clinical suspicion and wide excision are recommended, along with the need of establishing oncological guidelines for better prognosis.
毛母质癌是一种罕见且侵袭性强的恶性肿瘤，起源于毛囊基质细胞，10%的病例具有肺和区域淋巴结转移潜能。我们报告一例54岁男性患者，其经活检证实为胸部恶性毛母质瘤，此前切除后多次复发。由于肿瘤大小（28×22厘米），行广泛切除及Ⅰ级和Ⅱ级腋窝淋巴结清扫术，随后采用游离腹壁下深动脉穿支皮瓣重建并辅助放疗。由于其罕见性，该肿瘤最初可能被误诊，若切除不充分会导致治疗延迟和复发。此外，肿瘤体积大与转移发生率较高相关。建议提高临床怀疑指数并进行广泛切除，同时需要制定肿瘤学指南以改善预后。
