Department of Clinical Sciences, Cornell University, Ithaca, NY 14543, USA.
Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Regen Med. 2020 Jun;15(6):1775-1787. doi: 10.2217/rme-2019-0143. Epub 2020 Aug 18.
Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum. The purpose of this manuscript is to disseminate findings from a workshop on the development of translational regenerative medicine in the equine field. Five themes emerged: stem cell characterization and tenogenic differentiation; interactions between mesenchymal stem cells, other cells and the environment; scaffolds and cell packaging; blood- and bone marrow-based regenerative medicines; clinical use of regenerative therapies. Evidence gained through the use of regenerative medicine applications in the horse should continue to translate to the human patient, bringing novel regenerative therapies to both humans and horses.
再生医学在人类和马的运动员中被广泛应用。潜在的治疗方法包括培养扩增的干细胞、脂肪组织的基质血管部分、富含血小板的血浆、骨髓浓缩物或自体条件血清。本文的目的是传播关于在马领域开发转化再生医学的研讨会的结果。出现了五个主题：干细胞的特征和腱形成分化；间充质干细胞、其他细胞和环境之间的相互作用；支架和细胞包装；基于血液和骨髓的再生医学；再生疗法的临床应用。通过在马中使用再生医学应用获得的证据应继续转化为人类患者，为人类和马带来新的再生疗法。
