Reversine enhances skin barrier functions by suppressing the IL-4- and IL-13-mediated STAT6 pathway.
作者信息
Park Yukyung, Jung Janghwan, Jeong Sunmun, van Ee Amy, Garza Luis A, Jang Minsoo, Kim Dongwon, Park Jongbin
机构信息
Graduate School of Energy/Biotechnology, Dongseo University, Busan, Republic of Korea.
Department of Dermatology, Kosin University College of Medicine, Busan, Republic of Korea.
出版信息
J Dermatol Sci. 2023 Aug;111(2):71-73. doi: 10.1016/j.jdermsci.2023.06.006. Epub 2023 Jun 27.
Abstract
摘要
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Reversine enhances skin barrier functions by suppressing the IL-4- and IL-13-mediated STAT6 pathway.逆转素通过抑制白细胞介素-4和白细胞介素-13介导的信号转导和转录激活因子6（STAT6）途径来增强皮肤屏障功能。
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本文引用的文献
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The JAK/STAT signaling pathway: from bench to clinic.JAK/STAT 信号通路：从基础到临床。
Signal Transduct Target Ther. 2021 Nov 26;6(1):402. doi: 10.1038/s41392-021-00791-1.
2
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.IL-4、IL-13、IL-17A、IL-22、AHR 和 NRF2 对丝聚合蛋白、兜甲蛋白和 Involucrin 的调节：特应性皮炎的发病机制。
Int J Mol Sci. 2020 Jul 29;21(15):5382. doi: 10.3390/ijms21155382.
3
Reversine exhibits antineoplastic activity in JAK2-positive myeloproliferative neoplasms.雷维塞昔在 JAK2 阳性骨髓增殖性肿瘤中具有抗肿瘤活性。
Sci Rep. 2019 Jul 9;9(1):9895. doi: 10.1038/s41598-019-46163-2.
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Reversine: A Synthetic Purine with a Dual Activity as a Cell Dedifferentiating Agent and a Selective Anticancer Drug.雷维辛：一种具有双重活性的合成嘌呤，可作为细胞去分化剂和选择性抗癌药物。
Curr Med Chem. 2020;27(21):3448-3462. doi: 10.2174/0929867326666190103120725.
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Possible roles of basophils in chronic itch.嗜碱性粒细胞在慢性瘙痒中的可能作用。
Exp Dermatol. 2019 Dec;28(12):1373-1379. doi: 10.1111/exd.13705. Epub 2018 Aug 7.
6
New insights in the pathogenesis of atopic dermatitis.特应性皮炎发病机制的新见解。
Pediatr Res. 2014 Jan;75(1-2):171-5. doi: 10.1038/pr.2013.196. Epub 2013 Nov 5.
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Reversine, a 2,6-disubstituted purine, as an anti-cancer agent in differentiated and undifferentiated thyroid cancer cells.雷维塞丁，一种 2,6-二取代嘌呤，作为分化型和未分化型甲状腺癌细胞中的抗癌剂。
Pharm Res. 2012 Jul;29(7):1990-2005. doi: 10.1007/s11095-012-0727-3. Epub 2012 Apr 4.
8
Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes.细胞外双链 RNA 通过人类角质形成细胞中的内体酸化和 NF-κB 依赖途径诱导 TSLP。
J Invest Dermatol. 2011 Nov;131(11):2205-12. doi: 10.1038/jid.2011.185. Epub 2011 Jun 30.
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Dedifferentiation of lineage-committed cells by a small molecule.小分子诱导谱系定向细胞去分化
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Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication.正常的和c-Myc促进的人角质形成细胞分化均通过涉及细胞生长和核内复制的新型细胞周期发生。
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