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乳腺癌疫苗:挑战与突破

Vaccines in Breast Cancer: Challenges and Breakthroughs.

作者信息

Fatima Gul Naz, Fatma Hera, Saraf Shailendra K

机构信息

Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Lucknow 226028, Uttar Pradesh, India.

出版信息

Diagnostics (Basel). 2023 Jun 26;13(13):2175. doi: 10.3390/diagnostics13132175.

DOI:10.3390/diagnostics13132175
PMID:37443570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10340541/
Abstract

Breast cancer is a problem for women's health globally. Early detection techniques come in a variety of forms ranging from local to systemic and from non-invasive to invasive. The treatment of cancer has always been challenging despite the availability of a wide range of therapeutics. This is either due to the variable behaviour and heterogeneity of the proliferating cells and/or the individual's response towards the treatment applied. However, advancements in cancer biology and scientific technology have changed the course of the cancer treatment approach. This current review briefly encompasses the diagnostics, the latest and most recent breakthrough strategies and challenges, and the limitations in fighting breast cancer, emphasising the development of breast cancer vaccines. It also includes the filed/granted patents referring to the same aspects.

摘要

乳腺癌是全球女性健康面临的一个问题。早期检测技术形式多样,从局部到全身,从非侵入性到侵入性。尽管有各种各样的治疗方法,但癌症的治疗一直具有挑战性。这要么是由于增殖细胞行为多变和异质性,和/或个体对所应用治疗的反应。然而,癌症生物学和科学技术的进步改变了癌症治疗方法的进程。本综述简要涵盖了乳腺癌的诊断、最新和最近的突破性策略与挑战,以及抗击乳腺癌的局限性,重点强调了乳腺癌疫苗的发展。它还包括涉及相同方面的已提交/已授权专利。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/4536d966afb4/diagnostics-13-02175-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/d9d7983740f5/diagnostics-13-02175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/a2307d52db1a/diagnostics-13-02175-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/531a251111d6/diagnostics-13-02175-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/4536d966afb4/diagnostics-13-02175-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/d9d7983740f5/diagnostics-13-02175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/a2307d52db1a/diagnostics-13-02175-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/531a251111d6/diagnostics-13-02175-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a62/10340541/4536d966afb4/diagnostics-13-02175-g004.jpg

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J Natl Cancer Cent. 2021 Jul 6;1(3):75-87. doi: 10.1016/j.jncc.2021.06.001. eCollection 2021 Sep.
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Targeting HER2-positive breast cancer: advances and future directions.针对 HER2 阳性乳腺癌:进展与未来方向。
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Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model.
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Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review.基于肽的疫苗在乳腺癌治疗中的临床阶段及新潜在治疗靶点:综述
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Significance of serum carcinoembryonic antigen in metastatic breast cancer patients: A prospective study.血清癌胚抗原在转移性乳腺癌患者中的意义:一项前瞻性研究。
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Breast cancer vaccines: New insights into immunomodulatory and nano-therapeutic approaches.乳腺癌疫苗:免疫调节和纳米治疗方法的新见解。
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Cancer vaccines: past, present and future; a review article.癌症疫苗:过去、现在与未来;一篇综述文章。
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A novel treatment strategy of HER2-targeted therapy in combination with Everolimus for HR+/HER2- advanced breast cancer patients with HER2 mutations.一种针对HER2突变的HR+/HER2-晚期乳腺癌患者的新型治疗策略,即HER2靶向治疗联合依维莫司。
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The current clinical landscape of personalized cancer vaccines.个性化癌症疫苗的当前临床概况。
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