Lupu Vasile Valeriu, Burlea Marin, Nistor Nicolai, Streanga Violeta, Starcea Magdalena Iuliana, Paduraru Gabriela, Ghica Dragos Catalin, Mitrofan Elena Cristina, Moscalu Mihaela, Ignat Ancuta
Pediatrics Department Preventive Medicine Department, University of Medicine and Pharmacy "Grigore T. Popa" Clinic of Pulmonary Disease Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy "Gr. T. Popa", Iasi, Romania.
Medicine (Baltimore). 2018 Sep;97(37):e12042. doi: 10.1097/MD.0000000000012042.
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy.72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix-Ochoa score), which also underwent the upper digestive endoscopy.Out of the 72 children diagnosed with GERD, 47 (65.28%) had grade A esophagitis and 25 (34.72%) grade B esophagitis. In GERD associated with grade B esophagitis the Boix-Ochoa score is statistically significant higher, compared with the GERD associated with grade A esophagitis (F = 9.76, P = .0036, 95% CI).Upper digestive endoscopy performed in patients with gastroesophageal reflux disease shows the constant presence of esophagitis at all patients. There were only grade A and B esophagitis due to the fact that they are young patients with a relative short history of the disease. The correlation tests show a perfect parallel between the pH-metry scores and the endoscopic lesion. The correlation is so accurate that the pH-metry scores can be sufficient to prove GERD and the grade of esophagitis, the upper digestive endoscopy being reserved only for the cases that does not respond to the medical treatment or have other complications.
胃食管反流（GER）是指胃内容物间歇性或持续性进入食管，而胃食管反流病（GERD）是指引发一系列症状或并发症的反流。本研究将用于诊断GERD的24小时食管pH监测与上消化道内镜检查所观察到的食管炎程度进行了比较。纳入了72名4岁以上的儿童，他们在罗马尼亚东北部的一家儿科胃肠病区域中心就诊，通过24小时pH监测（Boix - Ochoa评分呈阳性）被诊断为GERD，并且均接受了上消化道内镜检查。在这72名被诊断为GERD的儿童中，47名（65.28%）患有A级食管炎，25名（34.72%）患有B级食管炎。与A级食管炎相关的GERD相比，与B级食管炎相关的GERD的Boix - Ochoa评分在统计学上显著更高（F = 9.76，P = 0.0036，95%置信区间）。对胃食管反流病患者进行的上消化道内镜检查显示，所有患者均持续存在食管炎。仅出现了A级和B级食管炎，原因是他们都是患病时间相对较短的年轻患者。相关性测试显示pH监测评分与内镜病变之间存在完美的平行关系。这种相关性非常准确，以至于pH监测评分足以证明GERD和食管炎的等级，上消化道内镜检查仅保留用于对药物治疗无反应或有其他并发症的病例。
