Papadakos Stavros P, Stergiou Ioanna E, Gkolemi Nikolina, Arvanitakis Konstantinos, Theocharis Stamatios
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Cancers (Basel). 2023 Jun 30;15(13):3434. doi: 10.3390/cancers15133434.
Liver cancer is a complex and challenging disease with limited treatment options and dismal prognosis. Understanding the underlying molecular mechanisms driving liver cancer progression and metastasis is crucial for developing effective therapeutic strategies. The EPH/ephrin system, which comprises a family of cell surface receptors and their corresponding ligands, has been implicated in the pathogenesis of HCC. This review paper aims to provide an overview of the current understanding of the role of the EPH/ephrin system in HCC. Specifically, we discuss the dysregulation of EPH/ephrin signaling in HCC and its impact on various cellular processes, including cell proliferation, migration, and invasion. Overall, the EPH/ephrin signaling system emerges as a compelling and multifaceted player in liver cancer biology. Elucidating its precise mechanisms and understanding its implications in disease progression and therapeutic responses may pave the way for novel targeted therapies and personalized treatment approaches for liver cancer patients. Further research is warranted to unravel the full potential of the EPH/ephrin system in liver cancer and its clinical translation.
肝癌是一种复杂且具有挑战性的疾病，治疗选择有限，预后不佳。了解驱动肝癌进展和转移的潜在分子机制对于制定有效的治疗策略至关重要。EPH/ephrin系统由一类细胞表面受体及其相应配体组成，已被认为与肝癌的发病机制有关。这篇综述旨在概述目前对EPH/ephrin系统在肝癌中作用的理解。具体而言，我们讨论了肝癌中EPH/ephrin信号传导的失调及其对各种细胞过程的影响，包括细胞增殖、迁移和侵袭。总体而言，EPH/ephrin信号系统在肝癌生物学中是一个引人注目的多面角色。阐明其精确机制并了解其在疾病进展和治疗反应中的意义，可能为肝癌患者的新型靶向治疗和个性化治疗方法铺平道路。有必要进一步研究以揭示EPH/ephrin系统在肝癌中的全部潜力及其临床转化。
