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沙特阿拉伯利雅得地区医院急性冠状动脉综合征患者生活质量与药物处方模式的前瞻性横断面研究

A Prospective Cross-Sectional Study of Acute Coronary Syndrome Patients' Quality of Life and Drug Prescription Patterns at Riyadh Region Hospitals, Saudi Arabia.

作者信息

Balaha Mohamed F, Alamer Ahmed A, Kabel Ahmed M, Aldosari Saad A, Fatani Sarah

机构信息

Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

Pharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.

出版信息

Healthcare (Basel). 2023 Jul 7;11(13):1973. doi: 10.3390/healthcare11131973.

Abstract

Acute coronary syndrome (ACS) is a leading cause of cardiovascular-related morbidity and mortality worldwide. The present study investigated the health-related quality of life (HRQOL) and drug prescribing patterns in ACS patients at Riyadh hospitals in Saudi Arabia. This study was a 12-month prospective cross-sectional study that included 356 patients with ACS. The current study showed that younger male (67.42%) and urban (75.84%) patients suffered more from ACS. Moreover, most patients with NSTEMI (51.69%) experienced Grade 1 dyspnea (33.43%) and NYHA Stage 2 (29.80%); however, STEMI patients were at greater mortality risk. The HRQOL questionnaire showed that ACS patients were significantly impaired in all QOL domains (emotional [23.0%, = 0.001], physical [24.4%, = 0.003], and social [27.2%, = 0.002]). Furthermore, the most commonly prescribed medications were statins (93%), antiplatelets (84%), anticoagulants (79%), coronary vasodilators (65%), and beta-blockers (63%). Additionally, 64% of patients received PCIs or CABGs, with the majority of cases receiving PCIs (49%), whereas 9% received dual anticoagulant therapy. Thus, there is an urgent need to educate healthcare teams about the relevance of QOL in ACS control and prevention and the new ACS management recommendations. ACS is also growing among younger people, requiring greater attention and prevention.

摘要

急性冠状动脉综合征(ACS)是全球心血管相关发病和死亡的主要原因。本研究调查了沙特阿拉伯利雅得医院ACS患者的健康相关生活质量(HRQOL)和药物处方模式。本研究是一项为期12个月的前瞻性横断面研究,纳入了356例ACS患者。当前研究表明,年轻男性(67.42%)和城市患者(75.84%)患ACS的情况更为严重。此外,大多数非ST段抬高型心肌梗死(NSTEMI)患者(51.69%)经历1级呼吸困难(33.43%)和纽约心脏协会(NYHA)2级(29.80%);然而,ST段抬高型心肌梗死(STEMI)患者的死亡风险更高。HRQOL问卷显示,ACS患者在所有生活质量领域均有显著受损(情绪[23.0%,P = 0.001]、身体[24.4%,P = 0.003]和社会[27.2%,P = 0.002])。此外,最常用的药物是他汀类药物(93%)、抗血小板药物(84%)、抗凝剂(79%)、冠状动脉血管扩张剂(65%)和β受体阻滞剂(63%)。此外,64%的患者接受了经皮冠状动脉介入治疗(PCI)或冠状动脉旁路移植术(CABG),大多数病例接受PCI(49%),而9%接受双重抗凝治疗。因此,迫切需要对医疗团队进行教育,使其了解生活质量在ACS控制和预防中的相关性以及新的ACS管理建议。ACS在年轻人中的发病率也在上升,需要更多关注和预防。

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