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用于可生物降解植入应用的镁合金聚合物涂层综述

Polymeric Coatings for Magnesium Alloys for Biodegradable Implant Application: A Review.

作者信息

Keerthiga G, Prasad M J N V, Vijayshankar Dandapani, Singh Raman R K

机构信息

IITB-Monash Research Academy, Mumbai 400076, Maharashtra, India.

Microstructural Engineering and Mechanical Performance Laboratory, Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.

出版信息

Materials (Basel). 2023 Jun 29;16(13):4700. doi: 10.3390/ma16134700.

Abstract

Magnesium (Mg) alloys are a very attractive material of construction for biodegradable temporary implants. However, Mg alloys suffer unacceptably rapid corrosion rates in aqueous environments, including physiological fluid, that may cause premature mechanical failure of the implant. This necessitates a biodegradable surface barrier coating that should delay the corrosion of the implant until the fractured/damaged bone has healed. This review takes a brief account of the merits and demerits of various existing coating methodologies for the mitigation of Mg alloy corrosion. Since among the different coating approaches investigated, no single coating recipe seems to address the degradation control and functionality entirely, this review argues the need for polymer-based and biodegradable composite coatings.

摘要

镁(Mg)合金是用于可生物降解临时植入物的极具吸引力的结构材料。然而,镁合金在包括生理流体在内的水性环境中腐蚀速率过快,令人无法接受,这可能导致植入物过早出现机械故障。因此需要一种可生物降解的表面阻隔涂层,该涂层应延缓植入物的腐蚀,直到骨折/受损骨骼愈合。本文简要介绍了各种现有涂层方法在减轻镁合金腐蚀方面的优缺点。由于在所研究的不同涂层方法中,似乎没有一种单一的涂层配方能完全解决降解控制和功能问题,因此本文认为需要基于聚合物的可生物降解复合涂层。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd0/10342800/3737cc247184/materials-16-04700-g003.jpg

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