Saglam Emel, Sener Gulsen, Bayrak Tulin, Bayrak Ahmet, Gorgulu Numan
Department of Internal Medicine, Bagcilar Training and Research Hospital, 34200 Istanbul, Turkey.
Department of Biochemistry, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey.
J Clin Med. 2023 Jun 27;12(13):4304. doi: 10.3390/jcm12134304.
Coronavirus disease 2019 (COVID-19) is a systemic disease which causes an increased inclination to thrombosis by leading to coagulation system activation and endothelial dysfunction. Our objective in this study is to determine whether ischemia-modified albumin (IMA) can be used as a new marker in patients with COVID-19 for evaluating the increased coagulation risk, pneumonic infiltration, and thus, prognosis.
Our study included 59 patients with COVID-19 compatible pneumonic infiltration on lung computed tomography (CT) who applied to and were hospitalized in the Internal Diseases Outpatient Clinic, then followed up and treated, as well as 29 healthy individuals with a negative COVID-19 rRT-PCR test without any additional disease. Hemogram, coagulation, routine biochemistry, and serum IMA activity parameters were studied.
In our study, the higher serum IMA level in COVID-19 patients with pneumonic infiltration compared to that of the healthy control group was found to be statistically significant. No significant correlation was found between the serum IMA levels and the coagulation and inflammation parameters in the 59 COVID-19 patients included.
Serum IMA levels in COVID-19 patients with pneumonic infiltration on CT were found to be higher than in the control group. Examination of biochemical parameters, especially thrombotic parameters that affect prognosis such as IMA, can be a guide in estimating pneumonic infiltration.
2019冠状病毒病（COVID-19）是一种全身性疾病，可通过导致凝血系统激活和内皮功能障碍而增加血栓形成倾向。本研究的目的是确定缺血修饰白蛋白（IMA）是否可作为COVID-19患者评估凝血风险增加、肺部浸润及预后的新标志物。
本研究纳入了59例在肺部计算机断层扫描（CT）上有符合COVID-19表现的肺部浸润、并在内科门诊就诊及住院治疗并接受随访的患者，以及29例COVID-19逆转录聚合酶链反应（rRT-PCR）检测阴性且无其他疾病的健康个体。研究了血常规、凝血、常规生化及血清IMA活性参数。
在本研究中，发现COVID-19肺部浸润患者的血清IMA水平高于健康对照组，差异有统计学意义。在纳入的59例COVID-19患者中，血清IMA水平与凝血及炎症参数之间未发现显著相关性。
CT显示有肺部浸润的COVID-19患者血清IMA水平高于对照组。检测生化参数，尤其是影响预后的血栓形成参数如IMA，可为评估肺部浸润提供指导。
