Mas-Fontao Sebastian, Miranda-Serrano Blanca, Hernán David, López Raúl, Manso Paula, Dapena Fabiola, Sánchez-Tocino Mº Luz, Guerrero Jose, Pereira Mónica, Carneiro Damián, Iglesias Adriana, Piña Lola, Guerrero Elena, San Juan Marta, Ledesma Cristina, González Alicia, Rossignoli Araceli, Pereira Concepción, Burgos Marina, Sacristán Ana Mª, González-Parra Emilio, Arenas María Dolores
IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, 28029 Madrid, Spain.
J Clin Med. 2023 Jun 28;12(13):4337. doi: 10.3390/jcm12134337.
(1) Background: The impact of SARS-CoV-2 has been variable over the time course of the pandemic and in different populations. The aim was to analyze the impact of COVID-19 infection in a known population of hemodialysis (HD) patients and professionals in Spain at different times of the pandemic. (2) Methods: We conducted an observational, descriptive study with a follow-up from 3 March 2020 to 23 April 2022 (776 days), using in average of 414 professionals and 1381 patients from 18 HD units in Spain. The data from the positive PCR or the rapid antigen detection test (RADT) subject were analyzed and segmented into six periods (waves). (3) Results: Of 703 positive COVID-19 tests, 524 were HD patients (74.5%), and 179 were HD professionals (25.5%). Overall, 38% of staff and 43% of patients were affected. Differences were observed in regard to incidence (21% vs. 13%), mortality (3.5% vs. 0%), and symptomatology between the patients and professionals and throughout the pandemic. (4) Conclusions: COVID-19 severity varied during different pandemic waves, with a greater impact seen in the first wave. HD professionals and patients had similar infection rates, but patients had higher mortality rates. Community transmission was the primary route of infection.
(1) 背景：在新冠疫情的时间进程中以及不同人群中，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的影响存在差异。目的是分析在西班牙已知的血液透析（HD）患者和专业人员群体中，新冠病毒感染在疫情不同时期的影响。(2) 方法：我们进行了一项观察性描述性研究，随访时间从2020年3月3日至2022年4月23日（776天），平均纳入了西班牙18个血液透析单位的414名专业人员和1381名患者。对聚合酶链反应（PCR）阳性或快速抗原检测（RADT）阳性受试者的数据进行分析，并划分为六个时期（波次）。(3) 结果：在703例新冠病毒检测阳性病例中，524例为血液透析患者（74.5%），179例为血液透析专业人员（25.5%）。总体而言，38%的工作人员和43%的患者受到影响。在疫情期间，患者和专业人员在发病率（21%对13%）、死亡率（3.5%对0%）和症状方面存在差异。(4) 结论：在不同的疫情波次中，新冠病毒感染的严重程度有所不同，第一波次的影响更大。血液透析专业人员和患者的感染率相似，但患者的死亡率更高。社区传播是主要的感染途径。
