一项针对美国荷斯坦奶牛三种生育力性状的百万头奶牛全基因组关联研究。
A Million-Cow Genome-Wide Association Study of Three Fertility Traits in U.S. Holstein Cows.
机构信息
Department of Animal Science, University of Minnesota, Saint Paul, MN 55108, USA.
Animal Genomics and Improvement Laboratory, Agricultureal Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA.
出版信息
Int J Mol Sci. 2023 Jun 22;24(13):10496. doi: 10.3390/ijms241310496.
A genome-wide association study (GWAS) of the daughter pregnancy rate (DPR), cow conception rate (CCR), and heifer conception rate (HCR) using 1,001,374-1,194,736 first-lactation Holstein cows and 75,140-75,295 SNPs identified 7567, 3798, and 726 additive effects, as well as 22, 27, and 25 dominance effects for DPR, CCR, and HCR, respectively, with log(1/p) > 8. Most of these effects were new effects, and some new effects were in or near genes known to affect reproduction including , , and , and a gene cluster of pregnancy-associated glycoproteins. The confirmed effects included those in or near the and regions of Chr06 and the region of Chr01. Eleven SNPs in the region of Chr18, the region of Chr06, and the region of Chr01 with sharply negative allelic effects and dominance values for the recessive homozygous genotypes were recommended for heifer culling. Two SNPs in and near the region of Chr04 that were sharply negative for HCR and age at first calving, but slightly positive for the yield traits could also be considered for heifer culling. The results from this study provided new evidence and understanding about the genetic variants and genome regions affecting the three fertility traits in U.S. Holstein cows.
一项针对女儿妊娠率（DPR）、奶牛受胎率（CCR）和小母牛受胎率（HCR）的全基因组关联研究（GWAS），使用了 1001374-1194736 头首胎荷斯坦奶牛和 75140-75295 个 SNP，确定了 7567、3798 和 726 个加性效应，以及 22、27 和 25 个显性效应，用于 DPR、CCR 和 HCR，log(1/p) > 8。这些效应大多数是新的效应，一些新的效应位于或接近已知影响繁殖的基因，包括 、 和 ，以及妊娠相关糖蛋白的基因簇。已确认的效应包括 Chr06 的 和 区域以及 Chr01 的 区域内或附近的效应。Chr18 的 11 个 SNP、Chr06 的 区域和 Chr01 的 区域的 SNP，对于隐性纯合基因型具有强烈的等位基因效应和显性值，建议淘汰小母牛。Chr04 的 区域和附近的 2 个 SNP 对 HCR 和初配年龄有强烈的负向效应，但对产奶性状有轻微的正向效应，也可以考虑淘汰小母牛。本研究的结果为美国荷斯坦奶牛三个生育性状的遗传变异和基因组区域提供了新的证据和认识。
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