Tarquini B, Cecchettin M, Cariddi A
Int Arch Occup Environ Health. 1986;58(2):99-103. doi: 10.1007/BF00380760.
Gastrointestinal complaints, including peptic ulcer, are believed to be associated and enhanced by shift work (SW). However, there are no clear reports in the literature about this acquired pathology. Serum gastrin (G) and group I pepsinogen (PG1) are thought to play a role in the pathogenesis of peptic ulcer and may be considered a useful test of the gastric function. Five adult male foundry shift workers, without any demonstrated gastrointestinal pathology, were studied over a month's span during the following weekly rotating shift schedule: 07.45-16.45, 06.00-14.00, 14.00-22.00, 22.00-06.00. Six adult, day-working males acted as controls. Blood samples drawn at the beginning and at the end of each weekly shift were assayed for G and PG1 utilizing RIA kits. Our data showed that SW causes a prominent change in the gastrin/acidopepsin secretion system.
胃肠道不适，包括消化性溃疡，被认为与轮班工作（SW）有关且会因轮班工作而加重。然而，文献中尚无关于这种后天性病理状况的明确报道。血清胃泌素（G）和I组胃蛋白酶原（PG1）被认为在消化性溃疡的发病机制中起作用，并且可被视为胃功能的一项有用检测指标。五名成年男性铸造业轮班工人，无任何已证实的胃肠道病理状况，在接下来每周循环的轮班时间表中，历时一个月进行了研究：07:45 - 16:45、06:00 - 14:00、14:00 - 22:00、22:00 - 06:00。六名成年日班男性作为对照。利用放射免疫分析试剂盒对每个每周轮班开始和结束时采集的血样进行G和PG1检测。我们的数据表明，轮班工作会导致胃泌素/胃酸胃蛋白酶分泌系统发生显著变化。
