Tarquini B, Benvenuti M, Cavallini V, Cecchettin M, Romano S, Sensi G
Chronobiologia. 1984 Jan-Mar;11(1):11-7.
As compared to control subjects, patients with duodenal ulcer show decreased levels of serum G and increased levels of serum Group I pepsinogen (PGI). On the other hand, pregnant women in their third trimester show an increased level of serum G and decreased levels of serum PGI. Gastrin stimulates gastric secretion and has a trophic effect on the parietal cells. Concentrations of PGI in serum reflect the capacity of pepsin-secreting cells which are, in turn, closely related to the parietal cell mass. Pepsinogen/G ratio (PGI/G) could represent the effective acid-peptic secretory capacity. This study suggests that for screening and clinical purposes PGI/G ratio provides a good potentially discriminatory marker of gastric secreting capacity reliably correlating and improving the diagnostic significance of single G and/or PGI serum levels.
与对照组相比，十二指肠溃疡患者血清G水平降低，血清I组胃蛋白酶原（PGI）水平升高。另一方面，妊娠晚期妇女血清G水平升高，血清PGI水平降低。胃泌素刺激胃酸分泌，并对壁细胞有营养作用。血清中PGI的浓度反映了胃蛋白酶分泌细胞的能力，而胃蛋白酶分泌细胞又与壁细胞数量密切相关。胃蛋白酶原/胃泌素比值（PGI/G）可代表有效的胃酸分泌能力。本研究表明，用于筛查和临床目的时，PGI/G比值提供了一个良好的潜在鉴别标志物，可可靠地关联胃分泌能力，并提高单一G和/或PGI血清水平的诊断意义。
