Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
Staszica Mental Health Center, 15-071 Bialystok, Poland.
Int J Mol Sci. 2023 Jun 28;24(13):10751. doi: 10.3390/ijms241310751.
Alzheimer's disease is the most common cause of dementia in the world. Lack of an established pathology makes it difficult to develop suitable approaches and treatment for the disease. Besides known hallmarks, including amyloid β peptides cumulating in plaques and hyperphosphorylated tau forming NFTs, inflammation also plays an important role, with known connections to the diet. In AD, adhering to reasonable nutrition according to age-related principles is recommended. The diet should be high in neuroprotective foods, such as polyunsaturated fatty acids, antioxidants, and B vitamins. In addition, foods capable of rising BDNF should be considered because of the known profitable results of this molecule in AD. Adhering to beneficial diets might result in improvements in memory, cognition, and biomarkers and might even reduce the risk of developing AD. In this review, we discuss the effects of various diets, foods, and nutrients on brain health and possible connections to Alzheimer's disease.
阿尔茨海默病是世界上最常见的痴呆症病因。由于缺乏既定的病理学，因此很难为该疾病开发出合适的方法和治疗手段。除了众所周知的特征，包括在斑块中积累的淀粉样β肽和形成 NFT 的过度磷酸化 tau，炎症也起着重要作用，并且与饮食有已知的联系。在 AD 中，根据与年龄相关的原则，建议采用合理的营养。饮食应富含神经保护食物，如多不饱和脂肪酸、抗氧化剂和 B 族维生素。此外，应该考虑能够提高脑源性神经营养因子 (BDNF) 的食物，因为该分子在 AD 中的有益结果是已知的。坚持有益的饮食可能会改善记忆力、认知能力和生物标志物，甚至可能降低患 AD 的风险。在这篇综述中，我们讨论了各种饮食、食物和营养物质对大脑健康的影响以及与阿尔茨海默病的可能联系。
