Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.
Nutrients. 2022 May 6;14(9):1952. doi: 10.3390/nu14091952.
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has gained popularity in recent years in the context of neurological diseases (NDs). The complexity of the pathogenesis of these diseases means that effective forms of treatment are still lacking. Conventional therapy is often associated with increasing tolerance and/or drug resistance. Consequently, more effective therapeutic strategies are being sought to increase the effectiveness of available forms of therapy and improve the quality of life of patients. For the moment, it seems that KD can provide therapeutic benefits in patients with neurological problems by effectively controlling the balance between pro- and antioxidant processes and pro-excitatory and inhibitory neurotransmitters, and modulating inflammation or changing the composition of the gut microbiome. In this review we evaluated the potential therapeutic efficacy of KD in epilepsy, depression, migraine, Alzheimer's disease and Parkinson's disease. In our opinion, KD should be considered as an adjuvant therapeutic option for some neurological diseases.
生酮饮食（KD）是一种高脂肪、低碳水化合物和适量蛋白质的饮食，近年来在神经疾病（NDs）的背景下越来越受欢迎。这些疾病的发病机制非常复杂，这意味着仍然缺乏有效的治疗方法。传统的治疗方法往往伴随着耐受性的提高和/或耐药性的产生。因此，人们正在寻求更有效的治疗策略，以提高现有治疗方法的有效性并改善患者的生活质量。目前，KD 似乎可以通过有效控制促氧化剂和抗氧化剂之间的平衡以及促兴奋和抑制性神经递质之间的平衡，调节炎症或改变肠道微生物组的组成，为有神经问题的患者提供治疗益处。在这篇综述中，我们评估了 KD 在癫痫、抑郁、偏头痛、阿尔茨海默病和帕金森病中的潜在治疗效果。在我们看来，KD 应该被视为某些神经疾病的辅助治疗选择。
