类风湿关节炎发病机制的分子机制 1 和 2 的突破。
The Pathogenesis of Rheumatoid Arthritis Breakthroughs in Molecular Mechanisms 1 and 2.
机构信息
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
Division of Rheumatology, First Department of Comprehensive Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-0834, Japan.
出版信息
Int J Mol Sci. 2023 Jul 4;24(13):11060. doi: 10.3390/ijms241311060.
Abstract
The pathogenesis of rheumatoid arthritis (RA) consists of the formation of synovial villi, inflammation, immune abnormalities, and bone-cartilage destruction [...].
摘要
类风湿关节炎（RA）的发病机制包括滑膜绒毛的形成、炎症、免疫异常和骨软骨破坏[...]。
相似文献
1
The Pathogenesis of Rheumatoid Arthritis Breakthroughs in Molecular Mechanisms 1 and 2.类风湿关节炎发病机制的分子机制 1 和 2 的突破。
Int J Mol Sci. 2023 Jul 4;24(13):11060. doi: 10.3390/ijms241311060.
2
[Bone and cartilage destruction in rheumatoid arthritis].[类风湿关节炎中的骨与软骨破坏]
Clin Calcium. 2012 Feb;22(2):179-85.
3
Molecular biology of cartilage and bone destruction.软骨与骨破坏的分子生物学
Curr Opin Rheumatol. 1998 May;10(3):212-9. doi: 10.1097/00002281-199805000-00010.
4
FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis.类风湿关节炎中滑膜成纤维细胞以及软骨和骨侵蚀部位的FLICE抑制蛋白表达
Arthritis Rheum. 2002 Jun;46(6):1512-8. doi: 10.1002/art.10309.
5
1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.1,25 - 二羟基维生素D3与肿瘤坏死因子-α通过促进滑膜细胞中经由沉默调节蛋白1的p53乙酰化介导的细胞凋亡来预防类风湿性关节炎。
Cell Death Dis. 2016 Oct 20;7(10):e2423. doi: 10.1038/cddis.2016.300.
6
Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis.单克隆抗体抗集落刺激因子 1 受体在实验性关节炎中对骨骼和软骨的保护作用。
Arthritis Rheumatol. 2014 Nov;66(11):2989-3000. doi: 10.1002/art.38624.
7
Rheumatoid arthritis: regulation of synovial inflammation.类风湿性关节炎：滑膜炎症的调节
Int J Biochem Cell Biol. 2004 Mar;36(3):372-8. doi: 10.1016/s1357-2725(03)00259-0.
8
Giant cells, cartilage and bone fragments within rheumatoid synovial membrane: clinico-pathological correlations.类风湿性滑膜内的巨细胞、软骨和骨碎片：临床病理相关性
Australas Ann Med. 1970 May;19(2):105-10. doi: 10.1111/imj.1970.19.2.105.
9
Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats.中药配方芪七胶囊减轻大鼠类风湿性关节炎引起的炎症、滑膜增生和软骨破坏。
Arthritis Res Ther. 2018 Mar 14;20(1):43. doi: 10.1186/s13075-018-1547-6.
10
Cartilage damage and bone erosion are more prominent determinants of functional impairment in longstanding experimental arthritis than synovial inflammation.在长期实验性关节炎中，软骨损伤和骨质侵蚀比滑膜炎症更是功能障碍的突出决定因素。
Dis Model Mech. 2016 Nov 1;9(11):1329-1338. doi: 10.1242/dmm.025460. Epub 2016 Sep 16.
引用本文的文献
1
Spirulina supplementation and rheumatoid arthritis: A systematic review of current research and molecular mechanisms.补充螺旋藻与类风湿性关节炎：当前研究及分子机制的系统综述
Mol Biol Rep. 2025 Sep 17;52(1):921. doi: 10.1007/s11033-025-11048-3.
2
Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases.靶向治疗调节骨免疫疾病中 Th17/Treg 平衡的研究进展。
Front Immunol. 2024 Jan 30;15:1333993. doi: 10.3389/fimmu.2024.1333993. eCollection 2024.
本文引用的文献
1
New Insights into the Role of Synovial Fibroblasts Leading to Joint Destruction in Rheumatoid Arthritis.滑膜成纤维细胞在类风湿关节炎关节破坏中的作用新见解。
Int J Mol Sci. 2023 Mar 8;24(6):5173. doi: 10.3390/ijms24065173.
2
Serum Levels of IFABP2 and Differences in and Abundance on Gut Microbiota Are Associated with Poor Therapeutic Response in Rheumatoid Arthritis: A Pilot Study.血清 IFABP2 水平和肠道微生物群丰度的差异与类风湿关节炎治疗反应不良相关：一项初步研究。
Int J Mol Sci. 2023 Jan 19;24(3):1958. doi: 10.3390/ijms24031958.
3
Anti-Citrullinated Peptide Antibodies Control Oral and in Patients with Rheumatoid Arthritis.抗瓜氨酸化肽抗体可控制类风湿关节炎患者的口腔和。
Int J Mol Sci. 2022 Oct 20;23(20):12599. doi: 10.3390/ijms232012599.
4
Subgingival Microbiome in Rheumatoid Arthritis Patients with Periodontitis.类风湿关节炎伴牙周炎患者的龈下微生物组。
Int J Mol Sci. 2022 Aug 31;23(17):9883. doi: 10.3390/ijms23179883.
5
Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis.类风湿性关节炎的系统性骨质疏松症的发病机制。
Int J Mol Sci. 2022 Aug 5;23(15):8740. doi: 10.3390/ijms23158740.
6
Organokines in Rheumatoid Arthritis: A Critical Review.类风湿关节炎中的器官激酶：批判性评价。
Int J Mol Sci. 2022 May 31;23(11):6193. doi: 10.3390/ijms23116193.
7
Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity.2 型固有和适应性免疫调节的炎症性关节炎和骨代谢
Int J Mol Sci. 2022 Jan 20;23(3):1104. doi: 10.3390/ijms23031104.
8
14-3-3η Promotes Invadosome Formation via the FOXO3-Snail Axis in Rheumatoid Arthritis Fibroblast-like Synoviocytes.14-3-3η 通过 FOXO3-Snail 轴促进类风湿关节炎成纤维样滑膜细胞侵袭小体的形成。
Int J Mol Sci. 2021 Dec 23;23(1):123. doi: 10.3390/ijms23010123.
9
Shaping of Monocyte-Derived Dendritic Cell Development and Function by Environmental Factors in Rheumatoid Arthritis.环境因素对类风湿关节炎中单核细胞来源树突状细胞发育和功能的影响。
Int J Mol Sci. 2021 Dec 20;22(24):13670. doi: 10.3390/ijms222413670.
10
Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis.甲氨蝶呤改变类风湿关节炎成纤维样滑膜细胞中 microRNA 的表达。
Int J Mol Sci. 2021 Oct 26;22(21):11561. doi: 10.3390/ijms222111561.
Zotero 插件