College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Chengdu Center for Animal Disease Prevention and Control, Chengdu 610041, China.
Molecules. 2023 Jun 29;28(13):5115. doi: 10.3390/molecules28135115.
is a significant pathogen that can affect both human beings and animals. The extensive current use of antibiotics has resulted in antibiotic resistance. In our previous research, we found that zinc oxide quantum dots (ZnO QDs) had inhibitory effects on antibiotic-resistant microorganisms. In this study, a strain of with a broad antibiotic-resistant spectrum was isolated and identified from at Sichuan Agricultural University Teaching Animal Hospital. The genome for the resistance and virulence genes was analyzed. Additionally, the antibacterial effects and anti-virulence mechanism of ZnO QDs for were investigated. The results showed that the genome of is 1,943,955 bp, containing 22 resistance genes and 95 virulence genes. ZnO QDs have a good antibacterial effect against by reducing bacterial growth and decreasing the expression of virulence genes, including , , , and , which provides a novel potential treatment for .
是一种重要的病原体，能够感染人类和动物。目前抗生素的广泛使用导致了抗生素耐药性的出现。在我们之前的研究中，我们发现氧化锌量子点（ZnO QDs）对耐药微生物具有抑制作用。在这项研究中，我们从四川农业大学教学动物医院的分离并鉴定了一株具有广谱抗生素耐药性的 。分析了其耐药和毒力基因的基因组。此外，还研究了 ZnO QDs 对 的抗菌作用和抗毒力机制。结果表明，的基因组大小为 1943955bp，包含 22 个耐药基因和 95 个毒力基因。ZnO QDs 通过减少细菌生长和降低毒力基因的表达，对 具有良好的抗菌作用，包括 、 、 、和 ，为 提供了一种新的潜在治疗方法。
